Estrogens prevent calcium-induced release of cytochrome c from heart mitochondria
Estrogens prevent calcium-induced release of cytochrome c from heart mitochondria
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DOI：
10.1016/s0014-5793(02)02820-x
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发表时间：
2002-06-19
期刊：
影响因子：
3.5
通讯作者：
Borutaite, V
中科院分区：
文献类型：
--
作者：
Morkuniene, R;Jekabsone, A;Borutaite, V
我们研究了雌激素对心脏线粒体功能的影响，以及雌激素是否能阻止钙诱导的线粒体细胞色素c的释放。在状态3和状态4时，10 nM-10 muM、17 -雌二醇和4-羟他莫昔芬对线粒体呼吸速率和膜电位没有影响。较高浓度的两种药物降低状态3呼吸速率和膜电位。100 nM 17 -雌二醇和4-羟他莫昔芬阻断高钙诱导的线粒体细胞色素c释放，但对线粒体肿胀没有作用。因此，在生理浓度下，雌激素不影响线粒体呼吸功能，但保护心脏线粒体免受高钙诱导的细胞色素释放c. (c) 2002年由Elsevier Science B.V.代表欧洲生化学会联合会发表。
We investigated the effect of estrogens on heart mitochondrial functions and whether estrogens can prevent calcium-induced release of cytochrome c from mitochondria. 10 nM-10 muM 17beta-estradiol or 4-hydroxytamoxifen did not affect mitochondrial respiration rate and membrane potential in state 3 and state 4. Higher concentrations of both agents decreased state 3 respiration rate and membrane potential. 100 nM 17beta-estradiol and 4-hydroxytamoxifen blocked high calcium-induced cytochrome c release from mitochondria but not mitochondrial swelling. Thus, at physiological concentrations estrogens do not affect mitochondrial respiratory functions but protect heart mitochondria from high calcium-induced release of cytochrome c. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.