Translational Research in Cardiovascular Repair
Translational Research in Cardiovascular Repair
复制标题
心血管修复的转化研究
DOI：
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复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
R. Bolli
中科院分区：
文献类型：
--
作者：
S. Chamuleau;M. V. D. Naald;A. Climent;A. Kraaijeveld;K. Wever;D. Duncker;F. Fernández‐Avilés;R. Bolli
国际联盟TACTICS（心血管Syndrome再生治疗跨国联盟; https：//www.tacticsalliance.org/）最近提出了心脏修复细胞疗法领域的关键优先事项，将转化研究的功效确定为最终改善缺血性疾病患者生活质量的主要挑战之一。通过这篇代表TACTICS联盟撰写的文章，我们旨在提高对临床前研究中几个重要问题的认识，并提出建议，促进更严格的临床前工作，以提高其质量和可翻译性。最终，这些建议应该在研究人员的日常工作中以及机构、期刊和资助机构的政策中得到实施。临床前研究是必要的，不仅要了解基本机制，从而为新的治疗策略提供目标，而且要提供有关这些新策略的安全性和有效性的信息。此外，动物研究提供了机会来测试介入或侵入性方法的可行性，而不会伤害人类。显然，这些研究是在简化模型中进行的，不能完全反映临床情况。尽管如此，在心脏再生的临床前研究和临床试验中的效应大小之间存在相关性，尽管当从小动物模型（左心室射血分数，12%）移动到大动物模型（左心室射血分数，8%）和人（左心室射血分数，
The international consortium TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes; https://www.tacticsalliance.org/) has recently addressed key priorities in the field of cell-based therapy for cardiac repair, identifying the efficacy of translational research as one of the main challenges to ultimately improve the quality of life of patients with ischemic disease. With this article, written on behalf of the TACTICS consortium, we aim to increase awareness of several important issues in preclinical research and put forth proposals that should promote more rigorous preclinical work, in an effort to improve its quality and translatability. Ultimately, these recommendations should be implemented in the daily routine of investigators and in the policies of, institutions, journals, and funding agencies. Preclinical studies are necessary not only to understand basic mechanisms and thereby provide targets for new therapeutic strategies, but also to furnish information about the safety and efficacy of these new strategies. Furthermore, animal studies provide opportunities to test the feasibility of interventional or invasive approaches without the risk of harming humans. Obviously, these studies are performed in simplified models that do not completely reflect the clinical situation. Nevertheless, there is a correlation between effect size in preclinical studies and clinical trials for cardiac regeneration, although efficacy tends to drop when one moves from small animal models (∆left ventricular ejection fraction, 12%) to large animal models (∆left ventricular ejection fraction, 8%) and to humans (∆left ventricular ejection fraction,
影响因子：
24
作者：
Hariharan, Nirmala;Quijada, Pearl;Mohsin, Sadia;Joyo, Anya;Samse, Kaitlen;Monsanto, Megan;De La Torre, Andrea;Avitabile, Daniele;Ormachea, Lucia;McGregor, Michael J.;Tsai, Emily J.;Sussman, Mark A.
通讯作者：
Sussman, Mark A.
影响因子：
20.1
作者：
Gyöngyösi M;Wojakowski W;Lemarchand P;Lunde K;Tendera M;Bartunek J;Marban E;Assmus B;Henry TD;Traverse JH;Moyé LA;Sürder D;Corti R;Huikuri H;Miettinen J;Wöhrle J;Obradovic S;Roncalli J;Malliaras K;Pokushalov E;Romanov A;Kastrup J;Bergmann MW;Atsma DE;Diederichsen A;Edes I;Benedek I;Benedek T;Pejkov H;Nyolczas N;Pavo N;Bergler-Klein J;Pavo IJ;Sylven C;Berti S;Navarese EP;Maurer G;ACCRUE Investigators
通讯作者：
ACCRUE Investigators
提高心血管研究的严谨性和可重复性。
DOI：
10.1152/ajpheart.00524.2023
发表时间：
2023
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
Lindsey,MerryL;LeBlanc,AmandaJ;Bertrand,Luc;Bradshaw,AmyD;Kleinbongard,Petra
通讯作者：
Kleinbongard,Petra