A hydrazide-anchored dendron scaffold for chemoselective ligation strategies.
A hydrazide-anchored dendron scaffold for chemoselective ligation strategies.
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DOI：
10.1039/c4ob00870g
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发表时间：
2014-08
影响因子：
3.2
通讯作者：
Liz O'Donovan;Paul A. De Bank
中科院分区：
文献类型：
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作者：
Liz O'Donovan;Paul A. De Bank
化学选择性连接，包括“点击”化学，在一般的合成策略和聚合物和生物分子的特定修饰中发现了广泛的应用。这导致了这种方法的一些应用，特别是在生物医学领域，包括诊断成像和药物输送。然而，缺乏用特定药物、配体或标签的多个副本来化学选择性地装饰目标分子的工具。我们描述了一种肼锚定的树枝状支架的设计和合成，用于化学选择性地连接到羰基部分，并展示了它在RGD整合素结合配体修饰富醛表面的应用。
Chemoselective ligation, including "click" chemistry, has found wide utility in general synthetic strategies and the specific modification of polymers and biomolecules. This has resulted in a number of applications of such approaches, particularly in the biomedical area, including diagnostic imaging and drug delivery. However, tools to chemoselectively decorate target molecules with multiple copies of a particular drug, ligand or label are lacking. We describe the design and synthesis of a hydrazide-anchored dendron scaffold for chemoselective ligation to carbonyl moieties, and demonstrate its use in the modification of aldehyde-rich surfaces with the RGD integrin-binding ligand.