A CORRELATIVE MORPHOLOGICAL-STUDY OF HUMAN-BREAST AND ENDOMETRIUM IN THE MENSTRUAL-CYCLE
A CORRELATIVE MORPHOLOGICAL-STUDY OF HUMAN-BREAST AND ENDOMETRIUM IN THE MENSTRUAL-CYCLE
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DOI：
10.1097/00000478-198606000-00003
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发表时间：
1986-06-01
影响因子：
5.6
通讯作者：
BARTOW, SA
中科院分区：
文献类型：
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作者：
LONGACRE, TA;BARTOW, SA
选择在法医主持下尸检的 75 名绝经前妇女进行月经周期中乳房和子宫内膜形态的相关研究。选择标准包括充分保存子宫内膜和乳腺组织、按年龄（范围 15-56）、月经周期日期和产次状况划分的女性分布相对均匀。激素治疗和可能影响垂体-卵巢循环的疾病状态是被排除在该研究之外的原因。增殖期乳房的特点是小叶小，末端导管结构少。终末导管上皮有丝分裂并不常见。小叶内基质致密并与小叶间基质连续。分泌期乳房的特征是小叶尺寸增加、末端导管结构数量增加以及导管上皮基底空泡化和有丝分裂。小叶内间质变得越来越疏松和水肿。基质淋巴细胞数量在分泌期结束时增加。围经期乳房出现小叶收缩，导管上皮坏死和脱落。小叶间质淋巴细胞浸润和异染也随之显着增加。这些特征预示着增殖期外观的回归。这些显着的周期性变化对常规病理诊断以及更新的无创诊断技术具有影响。
Seventy-five premenopausal women autopsied under medical examiner auspices were selected for a correlative study of breast and endometrial morphology proceeding through the menstrual cycle. Criteria for selection included adequate preservation of the endometrial and breast tissue, relatively even distribution of women by age (range 15-56), menstrual cycle date, and parity status. Hormonal therapy and disease states that might influence pituitary-ovarian cycling were reasons for exclusion from the study. Proliferative phase breast was characterized by small lobules with few terminal duct structures. Terminal duct epithelial mitoses were uncommon. Intralobular stroma was condensed and continuous with interlobular stroma. Secretory phase breasts were characterized by increasing size of lobules and number of terminal duct structures and duct epithelial basal vacuolization and mitoses. Intralobular stroma became increasingly loose and edematous. Stromal lymphocytic population increased toward the end of secretory phase. Perimenstrual breasts underwent lobular contraction with necrosis and sloughing of duct epithelium. There was a concomitant marked increase in lobular stromal lymphocytic infiltrate and metachromasia. These features heralded a return to the proliferative phase appearance. These marked cyclical changes have implications for routine pathologic diagnosis as well as for the newer noninvasive diagnostic techniques.