Comparison of Immune Cell Recruitment and Function in Endometrium During Development of Epitheliochorial (Pig) and Hemochorial (Mouse and Human) Placentas
Comparison of Immune Cell Recruitment and Function in Endometrium During Development of Epitheliochorial (Pig) and Hemochorial (Mouse and Human) Placentas
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DOI：
10.1016/j.placenta.2008.09.019
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发表时间：
2009-03-01
期刊：
影响因子：
3.8
通讯作者：
Tayade, C.
中科院分区：
文献类型：
--
作者：
Croy, B. A.;Wessels, J.;Tayade, C.
母体免疫细胞在早期植入部位的作用受到生殖生物学家的特别关注，因为免疫细胞参与组织移植排斥反应。在正常怀孕期间，子宫内膜免疫细胞的亚群分布与血液中的免疫细胞不同，似乎是被激活的，但对受孕没有破坏性。免疫系统的进化早于胎盘哺乳动物。通过比较两种不同进化胎盘类型（猪（Sus scrofa）与小鼠（Mus musus）和人类（Homo sapiens））的系统发育分支中不同物种的子宫内膜免疫细胞的调节和功能，我们试图了解“非自我”滋养细胞如何在大多数妊娠中茁壮成长。我们的研究表明，特异性免疫细胞募集到与受孕相关的子宫内膜和免疫细胞促进的子宫内膜血管生成对哺乳动物受孕健康至关重要。(C) 2009年由IFPA和Elsevier Ltd出版
The role of maternal immune cells in early implantation sites has received special attention from reproductive biologists because immune cells participate in tissue transplant rejection. During normal pregnancy, endometrial immune cells differ from those in blood by subset distribution and appear to be activated but non-destructive of conceptuses. The immune system evolved well before placental mammals. By comparing the regulation and functions of endometrial immune cells between species in two phylogenetic clades that model differently evolved placental types (pig (Sus scrofa) versus mouse (Mus musculus) and human (Homo sapiens)), we seek to understand how "non-self' trophoblast cells thrive in most pregnancies. Our studies suggest recruitment of specific immune cells to conceptus-associated endometrium and immune cell-promoted endometrial angiogenesis are of key importance for mammalian conceptus well-being. (C) 2009 Published by IFPA and Elsevier Ltd