Study of stillbirth and major congenital anomaly among newborns in the high-level natural radiation areas of Kerala, India
Study of stillbirth and major congenital anomaly among newborns in the high-level natural radiation areas of Kerala, India
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DOI：
10.1007/s12687-012-0113-1
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发表时间：
2013-01-01
影响因子：
1.9
通讯作者：
Seshadri, M.
中科院分区：
文献类型：
--
作者：
Jaikrishan, G.;Sudheer, K. R.;Seshadri, M.
自1995年以来，在印度喀拉拉邦西南海岸的一个狭长地带-高水平自然辐射区及其周围地区，政府医院一直在监测新生儿的不良后果，如死产和重大先天性异常。含有钍的独居石砂及其子产物的天然沉积物是天然辐射水平升高的原因。在筛查的141，540名新生儿中[140，558例分娩：139，589例单胎，957例双胎（6.81%），11例三胎（0.078%）和1例四胎]，615例（4.35%）为死产，1，370例（9.68%）新生儿中观察到MCA。马蹄内翻足（404，2.85%）是最常见的MCA，其次是尿道下裂（152，2.10%）、先天性心脏病（168，1.19%）、唇腭裂（149，1.05%）、唐氏综合征（104，0.73%）和神经管缺陷（72，0.51%）。死产新生儿MCA的发生率为190.24%（117/615），活产新生儿MCA的发生率为8.89%（1,253/140,925），是活产新生儿MCA的20倍（P
Monitoring newborns for adverse outcomes like stillbirth and major congenital anomalies (MCA) is being carried out in government hospitals since 1995 in and around high-level natural radiation areas, a narrow strip of land on the southwest coast of Kerala, India. Natural deposits of monazite sand containing thoriumand its daughter products account for elevated levels of natural radiation. Among 141,540 newborns [140,558 deliveries: 139,589 singleton, 957 twins (6.81 %), 11 triplets (0.078 %), and one quadruplet] screened, 615 (4.35 %) were stillbirth and MCA were seen in 1,370 (9.68 %) newborns. Clubfoot (404, 2.85 %) was the most frequent MCA followed by hypospadias (152, 2.10% amongmale newborns), congenital heart disease (168, 1.19%), cleft lip/palate (149, 1.05%), Down syndrome (104, 0.73 %), and neural tube defects (72, 0.51 %). Newborns with MCA among stillbirths were about 20-fold higher at 190.24 % (117/615) compared to 8.89 % (1,253/140,925) among live births (P