Enantioselective Synthesis of Axially Chiral Vinyl Arenes through Palladium-catalyzed C-H Olefination
Enantioselective Synthesis of Axially Chiral Vinyl Arenes through Palladium-catalyzed C-H Olefination
复制标题
钯催化 C-H 烯化对映选择性合成轴向手性乙烯基芳烃
DOI：
10.1039/c8cc05555f
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Xu Li-Weng
中科院分区：
文献类型：
--
作者：
Sun Qiao-Ying;Ma Wei-Yang;Yang Ke-Fang;Cao Jian;Zheng Zhan-Jiang;Xu Zheng;Cui Yu-Ming;Xu Li-Weng
以多种烯烃为偶联剂，钯催化酮肟螯合辅助2-芳基环己烯酮肟醚的对映选择性碳氢烯烃化反应。以酮肟醚为导向基团，在温和的条件下，采用Pd（II）催化的C-H功能化方法合成了多种轴向手性乙烯基芳烃，其对映选择性为96→99% ee。
A palladium-catalyzed ketoxime-chelation-assisted enantioselective C–H olefination of 2-arylcyclohex-2-enone oxime ether with a wide range of olefins as coupling partners was developed. Employing ketoxime ether as an efficient directing group, a variety of axially chiral vinyl arenes was synthesized by Pd(II)-catalyzed C–H functionalization with excellent enantioselectivities (96 → 99% ee) under mild conditions.