Diffraction enhanced imaging contrast mechanisms in breast cancer specimens.
Diffraction enhanced imaging contrast mechanisms in breast cancer specimens.
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DOI：
10.1118/1.1507782
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发表时间：
2002-10
期刊：
影响因子：
3.8
通讯作者：
M. Hasnah;Z. Zhong;O. Oltulu;E. Pisano;R. E. Johnston;D. Sayers;W. Thomlinson;D. Chapman
中科院分区：
文献类型：
--
作者：
M. Hasnah;Z. Zhong;O. Oltulu;E. Pisano;R. E. Johnston;D. Sayers;W. Thomlinson;D. Chapman
本文研究了衍射增强成像技术（衍射增强成像技术，DEI）获得的折射角和表观吸收图像的对比机理，并将其与常规射线照相的吸收对比进行了比较。在肿瘤显像中，DEI折射角图像和x线片的对比度对组织密度差有相同的依赖性；在x线摄影中，这些差异直接与对比度有关，而在DEI折射角图像中，密度差和厚度梯度给出了折射角。我们表明，通过吸收图像测量的乳腺癌原纤维密度差与DEI折射角图像得出的密度差有很好的相关性。此外，我们发现DEI表观吸收图像和用DEI系统在反射率曲线顶部获得的图像具有比正常x线片大得多的对比度（高x8到33倍）。这是由于抑制了来自原纤维的小角度散射（消光），增强了对比度。
We have investigated the contrast mechanisms of the refraction angle, and the apparent absorption images obtained from the diffraction enhanced imaging technique (DEI) and have correlated them with the absorption contrast of conventional radiography. The contrast of both the DEI refraction angle image and the radiograph have the same dependence on density differences of the tissues in the visualization of cancer; in radiography these differences directly relate to the contrast while in the DEI refraction angle image it is the density difference and thickness gradient that gives the refraction angle. We show that the density difference of fibrils in breast cancer as measured by absorption images correlate well with the density difference derived from refraction angle images of DEI. In addition we find that the DEI apparent absorption image and the image obtained with the DEI system at the top of the reflectivity curve have much greater contrast than that of the normal radiograph (x8 to 33-fold higher). This is due to the rejection of small angle scattering (extinction) from the fibrils enhancing the contrast.