Clinical outcome of Burkholderia cepacia complex infection in cystic fibrosis adults.
Clinical outcome of Burkholderia cepacia complex infection in cystic fibrosis adults.
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DOI：
10.1016/j.jcf.2004.01.005
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发表时间：
2004-06-01
期刊：
影响因子：
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通讯作者：
Elborn, J S
中科院分区：
文献类型：
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作者：
Courtney, J M;Dunbar, K E A;Elborn, J S
背景：洋葱伯克霍尔德菌复合体（BCC）是感染囊性纤维化（CF）患者的最重要的微生物群之一。该研究的目的是研究BCC感染如何影响临床结果。方法：对19例感染BCC的CF成人和19例感染铜绿假单胞菌的对照组进行了为期4年的研究。记录各组患者每年1 s内最佳用力呼气量（FEV(1)）和体重指数（BMI），并计算年递减率。结果：与铜绿假单胞菌感染组相比，BCC感染组FEV(1)和BMI显著降低（p=0.001和p=0.009）。16例感染单一结核性伯克霍尔德菌的患者FEV(1)下降率明显高于感染多沃氏伯克霍尔德菌（n=3）或铜绿假单胞菌（p=0.01和p=0.01）的患者
BACKGROUND: The Burkholderia cepacia complex (BCC) is one of the most important groups of organisms infecting cystic fibrosis (CF) patients. The aim of the study was to examine how infection with BCC affects clinical outcome.METHODS: Nineteen CF adults infected with BCC and 19 controls infected with Pseudomonas aeruginosa were studied over a 4-year period. The best forced expiratory volume in 1 s (FEV(1)) and body mass index (BMI) for each year were recorded and annual rate of decline calculated.RESULTS: The BCC infected group displayed a significantly greater reduction of FEV(1) and BMI compared to the P. aeruginosa infected group (p=0.001 and p=0.009, respectively). Sixteen patients infected with a single Burkholderia cenocepacia strain had a significantly greater rate of FEV(1) decline compared to those infected with Burkholderia multivorans (n=3) or P. aeruginosa (p=0.01 and p