Mitochondrial mutations differentially affect aging, mutability and anesthetic sensitivity in Caenorhabditis elegans
Mitochondrial mutations differentially affect aging, mutability and anesthetic sensitivity in Caenorhabditis elegans
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DOI：
10.1016/s0047-6374(01)00259-7
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发表时间：
2001-08-01
影响因子：
5.3
通讯作者：
Sedensky, MM
中科院分区：
文献类型：
--
作者：
Hartman, PS;Ishii, N;Sedensky, MM
在线虫秀丽隐杆线虫中，先前已经分离出影响复合物I（气体-1）和复合物II（mev-1）的活性的突变，复合物I和复合物II是控制线粒体呼吸中的电子流的五种膜结合复合物中的两种。我们比较了gas-1和mev-1突变对线粒体功能影响的不同性状的影响。在复杂的I和II的突变都增加了自由基的敏感性，在发展和老龄化动物。然而，气体-1和mev-1突变差异影响突变性和麻醉敏感性。具体来说，气体-1麻醉过敏，但不是超变，而mev-1是超变，但显示正常的反应，麻醉剂。这些结果表明，复合物I和II可能在它们对行为和发育的影响上不同，并且与由其他生物体中的线粒体变化引起的表型的广泛变化一致。(C)2001爱思唯尔科学爱尔兰有限公司。保留所有权利。
In the nematode Caenorhabditis elegans, mutations have been previously isolated that affect the activities of Complex I (gas-1) and Complex II (mev-1), two of the five membrane-bound complexes that control electron flow in mitochondrial respiration. We compared the effects of gas-1 and mev-1 mutations on different traits influenced by mitochondrial function. Mutations in Complex I and II both increased sensitivity to free radicals as measured during development and in aging animals. However, gas-1 and mev-1 mutations differentially affected mutability and anesthetic sensitivity. Specifically, gas-1 was anesthetic hypersensitive but not hypermutable while mev-1 was hypermutable but displayed normal responses to anesthetics. These results indicate that Complexes I and II may differ in their effects on behavior and development, and are consistent with the wide variation in phenotypes that result from mitochondrial changes in other organisms. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.