Quantitative tractography reveals changes in the corticospinal tract in drug-naive children with attention-deficit/hyperactivity disorder
Quantitative tractography reveals changes in the corticospinal tract in drug-naive children with attention-deficit/hyperactivity disorder
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DOI：
10.1503/jpn.190024
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发表时间：
2020-03-01
影响因子：
4.3
通讯作者：
Huang, Xiaoqi
中科院分区：
文献类型：
--
作者：
Bu, Xuan;Yang, Chuang;Huang, Xiaoqi
背景过去，人们已经探讨了皮质脊髓束在注意力缺陷多动障碍（ADHD）儿童注意力不集中和冲动症状中的特殊作用。然而，据我们所知，没有研究确定了ADHD受影响的皮质脊髓束的确切区域。我们的目的是确定全面的改变皮质脊髓束和相关的神经心理学底物的白色物质的微观结构在ADHDMs.MethodsWe招募了38名药物幼稚儿童多动症和34个典型的发展控制。我们采用了一种基于束的定量方法来测量扩散参数沿着的轨迹的皮质脊髓束，我们进一步相关的变化与注意和反应抑制measurements.ResultsCompared with controls. ResultsADHD儿童表现出显着较低的分数各向异性和较高的径向扩散在水平的大脑脚，并且仅在右侧皮质脊髓束中内囊后肢水平处具有较高的各向异性分数。以及，增加分数各向异性在后肢的内囊呈负相关，与连续性能测试的注意力和反应时间呈正相关的Stroop颜色词测试;增加径向扩散率在右脚区域呈正相关，在Stroop test.LimitationsThe样本量相对较小的遗漏。此外，我们没有考虑ADHD的不同亚型，缺乏足够的能力来分析亚组差异。高阶扩散模型是需要在未来的白色物质study.ConclusionWe证明了特定的变化，在右皮质脊髓束多动症的儿童。注意力和反应抑制措施的相关性强调了皮质脊髓束障碍在ADHD中的功能重要性。
BackgroundThe specific role of the corticospinal tract with respect to inattention and impulsive symptoms in children with attentiondeficit/hyperactivity disorder (ADHD) has been explored in the past. However, to our knowledge, no study has identified the exact regions of the corticospinal tract that are affected in ADHD. We aimed to determine comprehensive alterations in the white matter microstructure of the corticospinal tract and underlying neuropsychological substrates in ADHD.MethodsWe recruited 38 drug-naive children with ADHD and 34 typically developing controls. We employed a tract-based quantitative approach to measure diffusion parameters along the trajectory of the corticospinal tract, and we further correlated alterations with attention and response inhibition measures.ResultsCompared with controls, children with ADHD demonstrated significantly lower fractional anisotropy and higher radial diffusivity at the level of cerebral peduncle, and higher fractional anisotropy at the level of the posterior limb of the internal capsule in the right corticospinal tract only. As well, increased fractional anisotropy in the posterior limb of the internal capsule was negatively correlated with continuous performance test attention quotients and positively correlated with reaction time on the Stroop Colour-Word Test; increased radial diffusivity in the right peduncle region was positively correlated with omissions in the Stroop test.LimitationsThe sample size was relatively small. Moreover, we did not consider the different subtypes of ADHD and lacked sufficient power to analyze subgroup differences. Higher-order diffusion modelling is needed in future white matter studies.ConclusionWe demonstrated specific changes in the right corticospinal tract in children with ADHD. Correlations with measures of attention and response inhibition underscored the functional importance of corticospinal tract disturbance in ADHD.