Plasma selenium levels and oxidative stress biomarkers: A gene-environment interaction population-based study
Plasma selenium levels and oxidative stress biomarkers: A gene-environment interaction population-based study
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DOI：
10.1016/j.freeradbiomed.2014.07.005
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发表时间：
2014-09-01
影响因子：
7.4
通讯作者：
Javier Chaves, F.
中科院分区：
文献类型：
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作者：
Galan-Chilet, Inmaculada;Tellez-Plaza, Maria;Javier Chaves, F.
硒暴露在预防慢性疾病中的作用是有争议的，特别是在硒充足的人群中。在高浓度下，硒暴露可能会增加氧化应激。研究评估参与氧化应激途径和硒的基因遗传变异的相互作用是稀缺的。我们评估了血浆硒浓度与氧化应激水平的横截面相关性，测量为氧化还原型谷胱甘肽比值（GSSG/GSH），丙二醛（MDA），和8-氧代-7，8-二氢鸟嘌呤（8-oxo-dG）在尿液中，和氧化应激候选基因的遗传变异的相互作用，在1445名男性和女性，年龄在18-85岁，来自西班牙的代表性样本。研究样本中血浆硒水平的几何平均值为84.76 μ g/L。在完全校正的模型中，比较血浆硒水平的最高五分位数与最低五分位数的氧化应激生物标志物水平的几何平均值比率对于GSSG/GSH为0.61（0.50-0.76），对于MDA为0.89（0.79-1.00），对于8-氧代-dG为1.06（0.96-1.18）。我们观察到硒暴露和氧化应激生物标志物的非线性剂量反应，血浆硒浓度高于110 μ g/L与8-oxo-dG正相关，但与GSSG/GSH和MDA负相关。此外，我们确定了与高硒水平下氧化应激标志物水平升高相关的潜在风险基因型。我们的研究结果支持高硒水平增加某些生物过程中的氧化应激。需要更多的研究来解开硒生物学的复杂性和潜在的基因-硒相互作用与人类健康结果的相关性。(C)2014爱思唯尔公司All rights reserved.
The role of selenium exposure in preventing chronic disease is controversial, especially in selenium-repleted populations. At high concentrations, selenium exposure may increase oxidative stress. Studies evaluating the interaction of genetic variation in genes involved in oxidative stress pathways and selenium are scarce. We evaluated the cross-sectional association of plasma selenium concentrations with oxidative stress levels, measured as oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8-oxo-7,8-dihydroguanine (8-oxo-dG) in urine, and the interacting role of genetic variation in oxidative stress candidate genes, in a representative sample of 1445 men and women aged 18-85 years from Spain. The geometric mean of plasma selenium levels in the study sample was 84.76 mu g/L. In fully adjusted models the geometric mean ratios for oxidative stress biomarker levels comparing the highest to the lowest quintiles of plasma selenium levels were 0.61 (0.50-0.76) for GSSG/GSH, 0.89 (0.79-1.00) for MDA, and 1.06 (0.96-1.18) for 8-oxo-dG. We observed nonlinear dose-responses of selenium exposure and oxidative stress biomarkers, with plasma selenium concentrations above similar to 110 mu g/L being positively associated with 8-oxo-dG, but inversely associated with GSSG/GSH and MDA. In addition, we identified potential risk genotypes associated with increased levels of oxidative stress markers with high selenium levels. Our findings support that high selenium levels increase oxidative stress in some biological processes. More studies are needed to disentangle the complexity of selenium biology and the relevance of potential gene-selenium interactions in relation to health outcomes in human populations. (C) 2014 Elsevier Inc. All rights reserved.