SPATIAL-LEARNING IMPAIRMENT IN MICE INFECTED WITH LEGIONELLA-PNEUMOPHILA OR ADMINISTERED EXOGENOUS INTERLEUKIN-1-BETA
SPATIAL-LEARNING IMPAIRMENT IN MICE INFECTED WITH LEGIONELLA-PNEUMOPHILA OR ADMINISTERED EXOGENOUS INTERLEUKIN-1-BETA
复制标题
DOI：
10.1006/brbi.1995.1012
复制
发表时间：
1995-06-01
影响因子：
15.1
通讯作者：
KLEIN, TW
中科院分区：
文献类型：
--
作者：
GIBERTINI, M;NEWTON, C;KLEIN, TW
研究了白细胞介素-1 β (IL1 β)对空间学习的影响：在Morris水迷宫训练前，C57BL/6小鼠每天注射重组小鼠IL1 β （100 ng/只）。在另一项实验中，小鼠感染了亚致死剂量的革兰氏阴性细菌（嗜肺军团菌；Lp）。感染后患病的小鼠分别给予抗il - 1 β抗体（100 μ g/只）或生理盐水，然后进行水迷宫训练。结果表明：(1)外源性il - 1 β阻断了空间学习的获得，(2)Lp感染减弱了该任务的学习，(3)尽管疾病持续，但Lp感染小鼠的循环il - 1 β使学习正常化。数据表明，认知障碍可能是细胞因子介导的疾病行为的一个组成部分。(C) 1995学术出版社，inc。
The effect of interleukin-1 beta (IL1 beta) on spatial learning was examined: In one experiment, C57BL/6 mice were given daily injections (100 ng/mouse) of recombinant murine IL1 beta prior to training on the Morris water maze. In another experiment, mice were infected with a sublethal dose of a gram-negative bacterium (Legionella pneumophila; Lp). Mice rendered ill by the infection were given either anti-IL1 beta antibodies (100 mu g/mouse) or saline and then trained on the water maze. Results indicated that (1) exogenous IL1 beta blocked acquisition of spatial learning, (2) Lp infection attenuated learning on this task, and (3) neutralizing circulating IL1 beta in Lp-infected mice normalized learning despite the continuation of the illness. The data indicate that cognitive impairment may be a component of cytokine-mediated sickness behavior. (C) 1995 Academic Press, inc.