Unraveling the Self-Assembly of Heterocluster Janus Dumbbells into Hybrid Cubosomes with Internal Double-Diamond Structure
Unraveling the Self-Assembly of Heterocluster Janus Dumbbells into Hybrid Cubosomes with Internal Double-Diamond Structure
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揭示异簇 Janus 哑铃自组装成具有内部双金刚石结构的混合立方体
DOI：
10.1021/jacs.8b08016
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发表时间：
2019-01-16
影响因子：
15
通讯作者：
Wang, Wei
中科院分区：
文献类型：
--
作者：
Liu, Hong-Kai;Ren, Li-Jun;Wang, Wei
立方体是由两亲物与双连续立方相自组装产生的双连续立方相颗粒，其产生了相互连接的纳米通道的复杂网络，赋予这些材料用于高级应用的特殊功能。另一方面，团簇是一类具有吸引力的分子，它们表现出与原子和纳米颗粒不同的有趣功能和性质。受脂质自组装的启发，并吸引到新的功能的集群，我们准备了特殊的异质簇Janus哑铃（HCJDs）组成的不同的纳米簇：即，聚氧乙烯和多面体低聚倍半硅氧烷。HCJD类似于常规的两亲物，因此，它们在溶液中通过将囊泡转化为海绵状聚集体而自组装成多面杂交立方体。导致平衡的多种机制，包括分子自组装，囊泡积累，膜融合，内部结构重组和立方晶体生长，有助于整个过程。在这些结果的基础上，我们提出了一种从基本分子设计到构建具有层次结构和高级功能的微米或纳米材料的自组装策略。
Cubosomes are bicontinuous cubic-phase particles generated by amphiphile self-assembly with bicontinuous cubic phases, which creates an intricate network of interconnected nanochannels that endow these materials with special functions for advanced applications. On the other hand, clusters are an attractive class of molecules that exhibit intriguing functions and properties that differ from those of atoms and nanoparticles. Inspired by lipid self-assembly and attracted to the new functionalities of clusters, we prepared special heterocluster Janus dumbbells (HCJDs) composed of dissimilar nanoclusters: namely, a polyoxometalate and a polyhedral oligomeric silsesquioxane. HCJDs resemble conventional amphiphiles and, as such, they self-assemble in solution into faceted hybrid cubosomes via the transformation of vesicles into spongelike aggregates. Multiple mechanisms that lead to equilibrium, including molecular self-assembly, vesicle accumulation, membrane fusion, inner-structure reorganization, and cubic crystal growth, contributed to the overall process. On the basis of these results, we proposed a strategy for self-assembly from basic molecular design that goes beyond traditional amphiphiles to the construction of micro- or nanomaterials with hierarchical structures and advanced functions.