Dilution as a Solution: Targeting Microbial Populations with a Simplified Dilution Strategy.
Dilution as a Solution: Targeting Microbial Populations with a Simplified Dilution Strategy.
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稀释作为解决方案：通过简化的稀释策略针对微生物种群。
DOI：
10.1128/msphere.00701-20
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发表时间：
2020
期刊：
影响因子：
4.8
通讯作者：
Seekatz,AnnaM
中科院分区：
文献类型：
--
作者：
Bhattacharjee,Disha;Seekatz,AnnaM
肠道微生物群是维持抵抗艰难梭菌感染的重要组成部分，艰难梭菌是一种在医疗保健和社区环境中日益受到关注的病原体。 J. M. Auchtung、E. C. Preisner、J. Collins、A. I. Lerma 和 R. A. Britton 最近发表的文章（mSphere 5:e00387-20, 2020，https://doi.org/10.1128/mSphere.00387-20）展示了一种创新方法，通过采用稀释方案测试不同的微生物来识别抑制艰难梭菌的微生物体外和体内混合物。这种方法可以促进特定微生物的识别和验证，这些微生物能够引发涉及微生物群的许多条件的感兴趣功能，而微生物群的复杂性和变异性往往会使因果关系复杂化。
The gut microbiota is an integral part of maintaining resistance against infection byClostridioides(Clostridium)difficile, a pathogen of increasing concern in both health care and community settings. The recent article by J. M. Auchtung, E. C. Preisner, J. Collins, A. I. Lerma, and R. A. Britton (mSphere 5:e00387-20, 2020, https://doi.org/10.1128/mSphere.00387-20) demonstrates an innovative approach to identify microbes that inhibit C. difficile by employing a dilution scheme to test different microbial mixturesin vitroandin vivo. This type of approach can advance the identification and validation of specific microbes that elicit functions of interest for many conditions involving the microbiota, of which the complexity and variability can often complicate causality.