Circulating Concentrations of Vitamin B6 and Kidney Cancer Prognosis: A Prospective Case-Cohort Study.
Circulating Concentrations of Vitamin B6 and Kidney Cancer Prognosis: A Prospective Case-Cohort Study.
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DOI：
10.1371/journal.pone.0140677
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Scelo G
中科院分区：
文献类型：
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作者：
Muller DC;Johansson M;Zaridze D;Moukeria A;Janout V;Holcatova I;Navratilova M;Mates D;Midttun Ø;Ueland PM;Brennan P;Scelo G
前瞻性队列研究发现，诊断前循环维生素 B6 与肾癌风险和肾癌预后呈负相关。我们通过对 630 名肾细胞癌 (RCC) 患者进行病例队列研究，调查了肾癌诊断时维生素 B6 的循环浓度是否与死亡风险相关。诊断时采集血液，并使用 LC-MS/MS 定量维生素 B6 浓度。使用 Cox 回归模型计算风险比 (HR) 和 95% 置信区间 (CI)。调整分期、年龄和性别后，B6 浓度最高的人的风险比最低四分之一的人的风险低 3 倍（HR4vs1 0.33，95% CI [0.18，0.60]）。这种负相关仅由 RCC 死亡驱动（HR4vs1 0.22，95% CI [0.11, 0.46]），而非其他原因导致的死亡（HR4vs1 0.89，95% CI [0.35, 2.28]，p 交互作用 = 0.008）。这些结果表明，循环维生素 B6 可以为肾癌患者提供超出肿瘤分期提供的额外预后信息。
Prospective cohort studies have found that prediagnostic circulating vitamin B6 is inversely associated with both risk of kidney cancer and kidney cancer prognosis. We investigated whether circulating concentrations of vitamin B6 at kidney cancer diagnosis are associated with risk of death using a case-cohort study of 630 renal cell carcinoma (RCC) patients. Blood was collected at the time of diagnosis, and vitamin B6 concentrations were quantified using LC-MS/MS. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Cox regression models. After adjusting for stage, age, and sex, the hazard was 3 times lower among those in the highest compared to the lowest fourth of B6 concentration (HR4vs1 0.33, 95% CI [0.18, 0.60]). This inverse association was solely driven by death from RCC (HR4vs1 0.22, 95% CI [0.11, 0.46]), and not death from other causes (HR4vs1 0.89, 95% CI [0.35, 2.28], p-interaction = 0.008). These results suggest that circulating vitamin B6 could provide additional prognostic information for kidney cancer patients beyond that afforded by tumour stage.