Novoamauromine and ent-Cycloechinulin: Two New Diketopiperazine Derivatives from Aspergillus novofumigatus

Novoamauromine and ent-Cycloechinulin: Two New Diketopiperazine Derivatives from Aspergillus novofumigatus
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DOI:
10.1248/cpb.58.717
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发表时间:
2010-05-01
影响因子:
1.7
通讯作者:
Kawai, Ken-ichi
Kawai, Ken-ichi
中科院分区:
医学4区
文献类型:
--
作者:
Ishikawa, Kazuki;Hosoe, Tomoo;Kawai, Ken-ichi

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从新生烟曲霉(Aspergillus novofumigatus)CBS 117520中分离到两个新的二酮哌嗪代谢产物:novoamauromine(1)和ent-cycloechinulin(2)。化合物1和2的结构是在光谱和化学研究的基础上确定的,其中包括对amauromine(3)和cycloechinulin(4)的光谱和理化数据的详细比较。
Two new diketopiperazine metabolites, novoamauromine (1) and ent-cycloechinulin (2) have been isolated from Aspergillus novofumigatus CBS117520. The structures of 1 and 2 were established on the basis of spectroscopic and chemical investigation, including a detailed comparison of the spectroscopic and physico-chemical data of amauromine (3) and cycloechinulin (4).