Predictive value of colour Doppler imaging in a prospective study of visual field progression in primary open-angle glaucoma
Predictive value of colour Doppler imaging in a prospective study of visual field progression in primary open-angle glaucoma
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DOI：
10.1111/j.1600-0420.2005.00567.x
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发表时间：
2005-12-01
期刊：
影响因子：
--
通讯作者：
Sánchez, M
中科院分区：
文献类型：
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作者：
Martínez, A;Sánchez, M
目的：评价眼动脉(OA)和睫状后短动脉(SPCA)的彩色多普勒成像(CDI)对原发性开角型青光眼(POAG)患者病情进展的预测价值。用CDI、视野检查、眼内压(IOP)和血压测量方法，分别在基线时和每隔6个月测量两组的阻力指数(RIS)。用COX回归分析这些血管RIS的预测能力。绘制OA和SPCAs RIS的受试者操作特征曲线，计算预测值、似然比和检验后概率。结果：36个月后，23只眼进展。进展眼平均(SD)RI为0.82(0.007)，SPCA为0.73(0.006)，无进展眼为0.70(0.007)，SPCA为0.63(0.006)。RIS的最佳评分分别为0.72分和0.65分。以此为界点，OA检测阳性率为90.5%。结论：在POAG伴高眼压的眼球中，OARIS或SPCAs可以可靠地预测视野进展。
Purpose: To assess the value of colour Doppler imaging (CDI) of the ophthalmic artery (OA) and short posterior ciliary arteries (SPCAs) in prognosis of disease progression in patients with primary open-angle glaucoma (POAG).Methods: A total of 49 eyes of 49 patients with POAG were included in a prospective cohort study. At baseline and every 6 months for 36 months, we measured the resistive indices (RIs) of the OA and SPCAs using CDI, visual field examination, intraocular pressure (IOP) and blood pressure measurements. The predictive capacity of the RIs of these vessels was investigated by Cox regression. Receiver operating characteristics curves were plotted for the OA and SPCAs RIs, and predictive values, likelihood ratios and post-test probabilities were calculated.Results: After 36 months, 23 eyes had progressed. In the eyes that progressed, the mean (SD) RI was 0.82 (0.007) for the OA and 0.73 (0.006) for the SPCAs; in the eyes that did not progress the mean RI was 0.70 (0.007) for the OA and 0.63 (0.006) for the SPCAs. The optimal points for the RIs were 0.72 for the OA and 0.65 for the SPCAs. With these cut-off points, the positive post-test probability was 90.5% in the OA.Conclusion: In eyes with POAG and elevated IOP, the RIs of the OA or SPCAs may reliably predict visual field progression.