HOMEOTIC TRANSFORMATIONS OF MURINE VERTEBRAE AND CONCOMITANT ALTERATION OF HOX CODES INDUCED BY RETINOIC ACID
HOMEOTIC TRANSFORMATIONS OF MURINE VERTEBRAE AND CONCOMITANT ALTERATION OF HOX CODES INDUCED BY RETINOIC ACID
复制标题
DOI：
10.1016/0092-8674(91)90574-i
复制
发表时间：
1991-10-04
期刊：
影响因子：
64.5
通讯作者：
GRUSS, P
中科院分区：
文献类型：
--
作者：
KESSEL, M;GRUSS, P
小鼠胚胎暴露于致畸剂量的维甲酸（RA）诱导椎骨的同源异型转化。后转换发生沿着完整的身体轴后，RA管理在妊娠第7天，并伴随着Hox基因表达域在胚胎中的前移。在第8.5天诱导脊柱尾侧半椎体的前转化。我们认为，脊椎节段的身份是由功能活跃的Hox基因的组合，一个“Hox密码”来指定的。“在这个概念中，Hox基因的顺序激活定义了顺序更靠后的轴向水平，而中胚层细胞离开原始条纹。外源性RA干扰Hox编码的正常建立，从而影响轴向特异性。
Exposure of murine embryos to teratogenic doses of retinoic acid (RA) induced homeotic transformations of vertebrae. Posterior transformations occurred along the complete body axis after RA administration on day 7 of gestation and were accompanied by anterior shifts of Hox gene expression domains in embryos. Anterior transformations of vertebrae in the caudal half of the vertebral column were induced on day 8.5. We suggest that the identity of a vertebral segment is specified by a combination of functionally active Hox genes, a "Hox code." In this concept the sequential activation of Hox genes defines sequentially more posterior axial levels, while mesodermal cells leave the primitive streak. Exogenous RA interferes with the normal estabishment of Hox codes and thus with axial specification.