Prazosin for Trauma Nightmares and Sleep Disturbances in Combat Veterans with Post-Traumatic Stress Disorder.
Prazosin for Trauma Nightmares and Sleep Disturbances in Combat Veterans with Post-Traumatic Stress Disorder.
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DOI：
10.17795/ijpbs-2603
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发表时间：
2016-09
影响因子：
1
通讯作者：
Ghadami MR
中科院分区：
文献类型：
--
作者：
Khazaie H;Nasouri M;Ghadami MR
哌唑嗪对减少创伤后应激障碍（PTSD）患者的睡眠障碍和创伤噩梦有显著效果;然而，对不同研究的结果进行了评价。目前的随机临床试验旨在评估哌唑嗪对患有慢性PTSD的退伍军人的睡眠参数和噩梦的影响。32名患有慢性战争引起的PTSD和痛苦噩梦的退伍军人被随机分为哌唑嗪组和安慰剂组，为期8周。主要症状采用临床医生管理的PTSD量表（CAPS）中的复发性痛苦梦项目进行定性，日间症状严重程度采用PTSD检查表（PCL）进行测量，客观睡眠质量评价采用体动仪。与安慰剂相比，哌唑嗪对白天症状的减少（P = 0.69）以及创伤相关噩梦的频率和强度无显著影响。此外，治疗前后体动计测量值之间无显著差异（P > 0.05）。研究结果表明，哌唑嗪对减少慢性PTSD退伍军人的PTSD症状和噩梦没有显着作用。需要进一步的临床试验来确定哌唑嗪对睡眠生理的影响，以及这种影响是否与治疗反应有关。
Prazosin is significantly effective to reduce sleep disturbance and trauma nightmare in patients with post-traumatic stress disorder (PTSD); however, results of different studies were evaluated. The current randomized clinical trial aimed to assess the effects of prazosin on sleep parameters and nightmares among veterans with chronic PTSD. Thirty-two veterans with chronic war-induced PTSD and distressing nightmares were randomized into prazosin and placebo groups for eight weeks. The main symptoms were qualified using the recurrent distressing dreams item of the clinician administered PTSD scale (CAPS) and the daytime symptom severity was measured by PTSD checklist (PCL) and the objective sleep quality assessment by actigraphy. Compared with placebo, prazosin had no significant effects on reduction of daytime symptoms (P = 0.69) and frequency and intensity of trauma-related nightmares. Also, there were no significant differences between pre- and post-treatment actigraphy measurements (P > 0.05). The study findings showed that prazosin had no significant effect on reduction of PTSD symptoms as well as nightmares among veterans with chronic PTSD. Further clinical trials are needed to define the effect of prazosin on sleep physiology and whether such effects regarding the therapeutic response.