Neurologic and Neurobehavioral Sequelae in Children With Human Immunodeficiency Virus (HIV-1) Infection
Neurologic and Neurobehavioral Sequelae in Children With Human Immunodeficiency Virus (HIV-1) Infection
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DOI：
10.1177/0883073811405203
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发表时间：
2011-11-01
影响因子：
1.9
通讯作者：
Wilmshurst, Jo M.
中科院分区：
文献类型：
--
作者：
Govender, Rajeshree;Eley, Brian;Wilmshurst, Jo M.
儿童人类免疫缺陷病毒（HIV-1）感染的神经和神经行为并发症的范围和程度描述不足。对78名HIV-1感染儿童（32名女性）的神经系统并发症进行了评估。46名儿童有异常的神经学检查。33名儿童有整体锥体束征，5名有轻偏瘫，4名有周围神经病变，18名有视力障碍，5名有听力障碍。63名1岁以上儿童中有39人存在神经行为问题。在24名患有艾滋病毒脑病的儿童中，74%的儿童有严重的免疫抑制，45%的儿童没有接受抗逆转录病毒治疗。12名儿童既往有机会性中枢神经系统感染，9名患有癫痫。不同的神经和神经行为缺陷在HIV-1感染儿童中很常见。患有严重免疫抑制的儿童，未接受抗逆转录病毒治疗，生长受损，年龄小于1岁，发生神经系统并发症的风险最大。
The range and extent of neurologic and neurobehavioral complications of human immunodeficiency virus (HIV-1) infection in children are under-described. Seventy-eight children with HIV-1 infection (32 females) were assessed for neurologic complications. Forty-six children had abnormal neurology examinations. Thirty-three children had global pyramidal tract signs, 5 had a hemiparesis, 4 had peripheral neuropathy, 18 had visual impairment, and 5 had hearing impairment. Thirty-nine of 63 children over 1 year of age had neurobehavioral problems. Of 24 children with HIV encephalopathy, 74% had severe immunosuppression and 45% were not receiving antiretroviral therapy. Twelve children had prior opportunistic central nervous system infections, and 9 had epilepsy. Diverse neurologic and neurobehavioral deficits are common in children with HIV-1 infection. Children with severe immunosuppression, who were not receiving antiretroviral therapy, were growth impaired and less than 1 year of age, were at greatest risk for developing neurologic complications.