Heart Rate Variability and Exercise in Aging Women
Heart Rate Variability and Exercise in Aging Women
复制标题
DOI：
10.1089/jwh.2011.2932
复制
发表时间：
2012-03-01
影响因子：
3.5
通讯作者：
Church, Timothy S.
中科院分区：
文献类型：
--
作者：
Earnest, Conrad P.;Blair, Steven N.;Church, Timothy S.
背景资料：我们的研究组在6个月的运动训练中显示出最大心肺运动能力（VO 2 max）和心率变异性（HRV）的正剂量反应，但对于≥ 60岁的女性，VO 2 max没有改善。在此，我们研究了年龄小于和大于60岁的绝经后妇女对运动训练的心率变异性反应。我们检查了365名久坐、超重、高血压、绝经后的妇女，她们被随机分配到久坐对照组或运动组，（4 kcal/kg/周，[KKW]）、100%（8 KKW）和150%（12 KKW）的美国国立卫生研究院（NIH）共识发展小组体力活动指南。主要结果包括时域和频域指数的HRV。结果：总体而言，我们的分析表明，在8 KKW和12 KKW的年龄层的副交感神经张力（rMSSD和高频功率）显着改善。rMSSD的年龄分层反应为：对照组，< 60岁，0.20 ms，95% CI-2.40，2.81; ≥ 60岁，0.07 ms，95% CI-3.64，3.79;>= 60岁，1.20 ms，95% CI-1.82，4.22; 8-KKW，< 60岁，3.61 ms，95% CI 0.88，6.34; >= 60岁，5.75 ms，95% CI 1.89，9.61;< 60岁，5.07 ms，95% CI 2.53，7.60; ≥ 60岁，4.28 ms，95% CI 0.42，8.14。结论：最大摄氧量和心率变异性是心血管病死亡的独立危险因素。尽管VO 2 max没有改善，但HRV的副交感神经指数在≥ 60岁的女性中增加。这在临床上很重要，因为HRV具有重要的CVD风险和心肺功能以外的神经内脏影响。
Background: Our group has shown a positive dose-response in maximal cardiorespiratory exercise capacity (VO2max) and heart rate variability (HRV) to 6months of exercise training but no improvement in VO2max for women >= 60 years. Here, we examine the HRVresponse to exercise training in postmenopausal women younger and older than 60 years.Methods: We examined 365 sedentary, overweight, hypertensive, postmenopausal women randomly assigned to sedentary control or exercise groups exercising at 50% (4 kcal/kg/week, [KKW]), 100% (8 KKW) and 150% (12 KKW) of the National Institutes of Health (NIH) Consensus Development Panel physical activity guidelines. Primary outcomes included time and frequency domain indices of HRV.Results: Overall, our analysis demonstrated a significant improvement in parasympathetic tone (rMSSD and high frequency power) for both age strata at 8 KKW and 12 KKW. For rMSSD, the age-stratified responses were: control, < 60 years, 0.20 ms, 95% confidence interval (CI) -2.40, 2.81; >= 60 years, 0.07 ms, 95% CI -3.64, 3.79; 4 KKW, < 60 years, 3.67 ms, 95% CI 1.55, 5.79; >= 60 years, 1.20 ms, 95% CI -1.82, 4.22; 8-KKW, < 60 years, 3.61 ms, 95% CI 0.88, 6.34; >= 60 years, 5.75 ms, 95% CI 1.89, 9.61; and 12-KKW, < 60 years, 5.07 ms, 95% CI 2.53, 7.60; >= 60 years, 4.28 ms, 95% CI 0.42, 8.14.Conclusions: VO2max and HRV are independent risk factors for cardiovascular disease (CVD) mortality. Despite no improvement in VO2max, parasympathetic indices of HRV increased in women >= 60 years. This is clinically important, as HRV has important CVD risk and neurovisceral implications beyond cardiorespiratory function.