Growing optic nerve fibers follow neighbors during embryogenesis.
Growing optic nerve fibers follow neighbors during embryogenesis.
复制标题
在胚胎发生过程中，视神经纤维的生长会跟随邻近的纤维生长。
DOI：
10.1073/pnas.77.7.4374
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发表时间：
1980
影响因子：
11.1
通讯作者：
Levinthal,C
中科院分区：
文献类型：
--
作者：
Bodick,N;Levinthal,C
应用计算机三维重建技术对斑马鱼视神经的胚胎发育过程进行了研究。视网膜神经节细胞的生长纤维与邻近细胞体的更成熟的纤维接触。在观察到的生长模式中，眼睛后面的光纤以这样一种方式排列，即光纤位置的直角坐标与其细胞体位置的极坐标近似成比例。我们认为，这种转变是通过一个简单的以下机制，将神经节细胞分化的时间和位置转化为一个明确的空间组织内的视神经。
The embryonic development of the optic nerve of the zebrafish, Brachydanio rerio, was studied by three-dimensional computer reconstruction from serial section electron micrographs. Growing fibers from retinal ganglion cells had growth cones in contact with more mature fibers from adjacent cell bodies. In the observed growth pattern, the optic fibers immediately behind the eye were ordered in such a way that the rectangular coordinates of the fiber positions were approximately proportional to the polar coordinates of their cell body positions. We suggest that this transformation is achieved by a simple following mechanism that translates the time and position of ganglion cell differentiation into a well-defined spatial organization within the optic nerve.