Dietary glycemic index and liver steatosis
Dietary glycemic index and liver steatosis
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DOI：
10.1093/ajcn/84.1.136
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发表时间：
2006-07-01
影响因子：
7.1
通讯作者：
Brighenti, Furio
中科院分区：
文献类型：
--
作者：
Valtuena, Silvia;Pellegrini, Nicoletta;Brighenti, Furio
背景：胰岛素抵抗(IR)和肝脏脂肪变性(LS)是相互关联的代谢紊乱，其患病率正在迅速增加，但饮食碳水化合物质量对LS的影响尚不清楚。目的：目的：描述IR和LS与总碳水化合物、总膳食纤维、血糖指数(GI)和饮食中的血糖负荷的关系。设计：这项研究是对247名表面健康的受试者的横断面评估，这些受试者没有病毒性、中毒性或自身免疫性肝炎的证据，也没有选择饮酒。以稳态模型评估指数作为IR的替代指标，以肝脏超声作为LS分级的替代指标。饮食数据通过使用3D食物记录来收集。结果：高级别LS(HG-LS)的患病率在饮食GI的四个分位数之间显著增加(P为趋势和0.034)：第四个四分位数(高GI)的HG-LS是前三个四分位数(低至中GI)的两倍，而与总碳水化合物、总膳食纤维或血糖负荷无关。在胰岛素敏感者(胰岛素抵抗模型评价指数的前3个四分位数)中，HG-LS的患病率在不同GI组之间无显著差异，但在胰岛素抵抗者(IR的稳态模型评价指数的第4个四分位数)中，高GI者的HG-LS患病率是低至中等GI者的两倍(P=0.005)。结论：高GI饮食习惯与HG-LS有关，尤其是在胰岛素抵抗者。因此，关于碳水化合物来源质量的饮食建议可能是预防或治疗代谢性LS的补充工具。
Background: Insulin resistance (IR) and liver steatosis (LS) are interlinked metabolic derangements whose prevalence is rapidly increasing, but the effect of dietary carbohydrate quality on LS is unknown.Objective: The objective was to describe the relation of IR and LS to total carbohydrate, total dietary fiber, and the glycemic index (GI) and glycemic load of the diet.Design: The study was a cross-sectional evaluation of 247 apparently healthy subjects who had no evidence of viral, toxic, or autoimmune hepatitis and who were unselected for alcohol intake. The homeostasis model assessment index was used as a surrogate measure of IR, and a liver echography was used as a proxy for LS grading. Dietary data were collected by using 3-d food records. Total carbohydrate intake, total dietary fiber, GI, and glycemic load were calculated by using a semiquantitative food-frequency questionnaire concerning the dietary sources of carbohydrates.Results: The prevalence of high-grade LS (HG-LS) increased significantly across quartiles of dietary GI (P for trend < 0.034): HG-LS in the 4th quartile (high GI) was twice that in the first 3 quartiles (low to medium GIs), whereas no relation was observed with total carbohydrates, total dietary fiber, or glycemic load. In insulin-sensitive subjects (first 3 quartiles of homeostasis model assessment index of IR), the prevalence of HG-LS did not differ significantly between GI groups, but, in insulin-resistant subjects (4th quartile of homeostasis model assessment index of IR), it was twice as high in those with high GI as in those with low to medium GIs (P = 0.005).Conclusions: High-GI dietary habits are associated with HG-LS, particularly in insulin-resistant subjects. Dietary advice on the quality of carbohydrate sources therefore may be a complementary tool for preventing or treating LS of metabolic origin.