Dietary factors in the epidemiology of cancer of the larynx.
Dietary factors in the epidemiology of cancer of the larynx.
复制标题
喉癌流行病学中的饮食因素。
DOI：
10.1093/oxfordjournals.aje.a113147
复制
发表时间：
1981
影响因子：
5
通讯作者：
Shedd,D
中科院分区：
文献类型：
--
作者：
Graham,S;Mettlin,C;Marshall,J;Priore,R;Rzepka,T;Shedd,D
格雷厄姆，S.(部门纽约州立大学布法罗分校社会与预防医学系，纽约，布法罗，14261)，C.梅特林，J.马歇尔，R.普赖尔，T.Rzepka和D.Shedd。饮食因素在喉癌流行病学中的作用.美国流行病学杂志，1981；113：675-80.对罗斯威尔公园纪念研究所的374名男性喉癌患者和381名非消化系统或呼吸系统疾病和非肿瘤的对照组进行了访谈.与其他研究人员一样，作者发现与吸烟有关的高风险以及与饮酒有关的风险。此外，研究发现，在饮食中摄入少量维生素A的男性的风险大约是摄入大量维生素A的男性的两倍。维生素C也是如此，所有这些关系都很重要，随着上述饮食成分摄入量的减少，风险以剂量-反应方式增加。当检查与维生素A和维生素C相关的风险时，控制吸烟和饮酒，与低摄入量相关的风险增加仍然存在。关于营养素的研究结果与对动物和组织培养的研究结果一致。然而，流行病学复制的稀疏性、方法的困难以及该领域的复杂性需要对这些关系进行大量的进一步研究。
Graham, S. (Dept. of Social and Preventive Medicine, State U. of New York at Buffalo, Buffalo, NY 14261), C. Mettlin, J. Marshall, R. Priore, T. Rzepka and D. Shedd. Dietary factors in the epidemiology of cancer of the larynx.Am J Epidemiol1981; 113: 675–80.Interviews were carried out with 374 male patients at Roswell Park Memorial Institute with cancer of the larynx and 381 controls with diseases other than of the digestive or respiratory system and other than neoplasms. As have other investigators, the authors found a high risk associated with smoking as well as a risk associated with alcohol ingestion. In addition, the study found that males ingesting low amounts of vitamin A in their diet had approximately twice the risk of those ingesting large amounts. The same was true for vitamin C. All of these relationships were significant, and risk increased in dose-response fashion with decreases in ingestion of the above-mentioned dietary constituents. When the risks associated with vitamins A and C were examined controlling for smoking and drinking, the risk enhancement associated with low ingestion persisted. The findings on nutrients are consistent with results of studies on animals and tissue cultures. Nevertheless, the sparse epidemiologic replication, the difficulties with the methods, and the complexity of the field demand substantial further inquiry on these relationships.