The phytoestrogen genistein promotes wound healing by multiple independent mechanisms
The phytoestrogen genistein promotes wound healing by multiple independent mechanisms
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DOI：
10.1016/j.mce.2010.02.026
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发表时间：
2010-06-10
影响因子：
4.1
通讯作者：
Hardman, Matthew J.
中科院分区：
文献类型：
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作者：
Emmerson, Elaine;Campbell, Laura;Hardman, Matthew J.
金雀异黄素与大豆对人类健康的有益作用有关，特别是在衰老的情况下。绝经后妇女全身雌激素减少会导致一系列与年龄相关的病变，包括皮肤伤口愈合延迟。我们之前已经表明，这种情况可以通过补充雌激素来逆转。然而，人们对金雀异黄素对皮肤的影响知之甚少，最重要的是，金雀异黄素对伤口愈合的影响尚未得到评估。10周大的卵巢切除小鼠接受17β-雌二醇或金雀异黄素全身治疗，金雀异黄素显着加速伤口修复，并抑制炎症反应。出乎意料的是，与ER拮抗剂ICI联合治疗对金雀异黄素的抗炎、促进愈合作用几乎没有影响，因此金雀异黄素的作用仅部分通过经典雌激素受体依赖性信号通路介导。事实上，我们报告说，皮肤中的替代（细胞类型特异性）信号机制在金雀异黄素治疗的反应中被激活 (C) 2010 Elsevier Ireland Ltd 版权所有
Genistein has been implicated in the beneficial effects of soy on human health, particularly in the context of ageing In post-menopausal women reduced systemic estrogen leads to a range of age-associated pathologies, including delayed cutaneous wound healing We have previously shown that this can be reversed by estrogen replacement. However, the effect of genistein on the skin is poorly understood and crucially the influence of genistein on wound healing has not been assessed 10-week-old ovariectomised mice were systemically treated with 17 beta-estradiol or genistein Genistein substantially accelerated wound repair, associated with a dampened inflammatory response. Unexpectedly, co-treatment with the ER antagonist ICI had little impact on the anti-inflammatory, healing promoting effects of genistein Thus genistein's actions are only partially mediated via classical estrogen receptor-dependent signalling pathways. Indeed, we report that alternative (cell-type specific) signalling mechanisms are activated in the skin in response to genistein treatment (C) 2010 Elsevier Ireland Ltd All rights reserved