In situ forming degradable networks and their application in tissue engineering and drug delivery
In situ forming degradable networks and their application in tissue engineering and drug delivery
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DOI：
10.1016/s0168-3659(01)00500-4
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发表时间：
2002-01-17
影响因子：
10.8
通讯作者：
Bowman, CN
中科院分区：
文献类型：
--
作者：
Anseth, KS;Metters, AT;Bowman, CN
将聚乙二醇型多功能大分子单体与聚乙烯醇进行光聚合，形成可降解的水凝胶网络。高度膨胀凝胶的降解行为是通过监测其质量损失、膨胀度和压缩模数的变化来表征的。实验结果表明，弹性模量随时间呈指数减小，而体积膨胀率呈指数增大。假想的一级反应动力学和交联型网络结构的降解机理成功地预测了实验观察到的这些性质随降解的趋势。一旦得到验证，提出的降解机制被扩展到将网络降解动力学和随后的网络结构变化与生物活性分子从这些动态系统中的释放行为关联起来。利用统计方法预测网络中交联链断裂的理论模型被用来预测由这些水凝胶产生的复杂的侵蚀轮廓。最后，这些大分子单体作为软骨组织工程的原位形成水凝胶结构的应用被证明，(C)2002爱思唯尔科学公司版权所有。
Multi functional macromers based on poly(ethylene glycol) and poly(vinyl alcohol) were photopolymerized to form degradable hydrogel networks. The degradation behavior of the highly swollen gels was characterized by monitoring changes in their mass loss, degree of swelling, and compressive modulus. Experimental results show that the modulus decreases exponentially with time, while the volumetric swelling ratio increases exponentially. A degradation mechanism assuming pseudo first-order hydrolysis kinetics and accounting for the structure of the crosslinked networks successfully predicted the experimentally observed trends in these properties with degradation. Once verified, the proposed degradation mechanism was extended to correlate network degradation kinetics, and subsequent changes in network structure, with release behavior of bioactive molecules from these dynamic systems. A theoretical model utilizing a statistical approach to predict the cleavage of crosslinks within the network was used to predict the complex erosion profiles produced by these hydrogels. Finally, the application of these macromers as in situ forming hydrogel constructs for cartilage tissue engineering is demonstrated, (C) 2002 Elsevier Science B.V. All rights reserved.