The Use of Dextran 70 as a Plasma Expander Increases the Intraoperative Bleeding in Total Hip Replacement
The Use of Dextran 70 as a Plasma Expander Increases the Intraoperative Bleeding in Total Hip Replacement
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使用右旋糖酐 70 作为血浆扩张器会增加全髋关节置换术中的术中出血
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
C. Tørholm
中科院分区：
文献类型：
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作者：
P. Seest Jørgensen;S. Rasmussen;C. Tørholm
在全髋关节置换术(THR)中，葡聚糖70被广泛用作血浆扩张剂和血栓预防药物。在一项REC-Hirudin多中心剂量发现研究中，我们中心大约三分之一的患者在手术开始时接受了葡聚糖70作为血浆扩张剂，其余的患者在手术前接受了血凝素治疗。术中平均出血量：1组为1572ml(770~3950ml)，2组为1160ml(500~2400ml)，差异有统计学意义(p=0.002)。术后平均出血量第1组为273ml(50~675ml)，第2组为229ml(0~870ml)，差异无统计学意义。总出血量第1组平均1846ml(850~4250ml)，第2组平均1451ml(620~2810ml)，差异有统计学意义(p=0.012)。关于输血需求量，第1组的中位数为2，5个单位(0-8个单位)，而第2组为1.7个单位(0-7个单位)(p=0.055)。使用右旋糖酐70作为血浆扩张剂导致术中出血显著增加。关键词：出血-葡聚糖-髋关节成形术。
In total hip replacement (THR) dextran 70 is widely used as a plasma expander and as a thromboprophylactic agent. In a rec-hirudin multicenter dose-finding study approximately one third of the patients in our center received dextran 70 as a plasma expander at the beginning of the operation, the remainder received Haemaccel preoperatively. The average intraoperative bleeding was 1,572 ml (770-3,950 ml) in group 1 (dextran) and 1,160 ml (500-2,400 ml) in group 2. This difference is statistically significant (p = 0.002). The average postoperative bleeding was in group 1,273 ml (50-675 ml) and in group 2, 229 ml (0-870 ml), the difference is not significant. Total bleeding was in average 1,846 ml (850-4,250 ml) in group 1 and 1,451 ml (620-2,810 ml) in group 2; this difference is statistically significant (p = 0.012). Regarding the transfusion requirement measured in units; a median of 2, 5 units (0-8 units) were used in group 1 as opposed to 1.7 units (0-7 units) in group 2 (p = 0.055). The use of dextran 70 as a plasma expander led to significantly increased intraoperative bleeding. Key Words: Bleeding—Dextran—Hiparthroplasty.