Adaptive predictive control of arterial blood pressure based on a neural network during acute hypotension
Adaptive predictive control of arterial blood pressure based on a neural network during acute hypotension
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DOI：
10.1114/b:abme.0000042225.19806.34
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发表时间：
2004-10-01
影响因子：
3.8
通讯作者：
Sunagawa, K
中科院分区：
文献类型：
--
作者：
Kashihara, K;Kawada, T;Sunagawa, K
在急性低血压中，控制平均动脉血压（MAP）的自动药物输注系统以前没有研究过，尽管许多研究已经研究了使用血管舒张药物控制术后高血压的MAP。因此，我们研究了在急性低血压期间使用神经网络（NN）方法自动控制MAP。基于MAP对25 μ g/ml去甲肾上腺素（NE）的响应，在计算机模拟中测试了比例-积分-微分（PID）控制、使用NN的自适应预测控制（APC（NN））、APC（NN）和PID的组合控制（APC（NN-PID））、模糊控制和模型预测控制。在6只麻醉的兔子中，使用25 μ g ml（-1）的NE，与未控制的条件相比，PID控制、APC（NN）和APC（NN-PID）防止了严重的低血压。在PID控制下，6只动物中有4只显示MAP振荡。使用50 μ g ml（-1）的NE，家兔的所有测试系统均从急性低血压中恢复，但在PID控制期间显示持续的MAP振荡。总之，利用神经网络的自适应预测控制系统可以促进自动化药物输注装置的发展，因为它提供了强大的控制，即使当急性或大的扰动和个体间的差异，在敏感性治疗剂发生。
In acute hypotension, an automated drug infusion system to control mean arterial blood pressure (MAP) has not been previously studied, though many investigations have examined the use of vasodilating drugs to control MAP in postoperative hypertension. Therefore, we examined an automated control of MAP during acute hypotension using a neural network (NN) approach. A proportional-integral-derivative (PID) control, an adaptive predictive control using a NN (APC(NN)), a combined control of APC(NN) and PID (APC(NN-PID)), a fuzzy control, and a model predictive control were tested in computer simulation based on the MAP response to norepinephrine (NE) of 25 mug ml(-1). In six anesthetized rabbits, using the NE of 25 mug ml(-1), the PID control, APC(NN), and APC(NN-PID) prevented severe hypotension compared to an uncontrolled condition. Under PID control, four of the six animals showed MAP oscillation. Using NE of 50 mug ml(-1), the rabbits recovered from acute hypotension for all systems tested but showed sustained MAP oscillation during PID control. In conclusion, utilization of a NN for adaptive predictive control systems could facilitate the development of an automated drug infusion apparatus because it provides robust control even when acute or large perturbations and inter-individual differences in the sensitivity to therapeutic agents occur.