Association of lipid profile alterations with severe forms of dengue in humans
Association of lipid profile alterations with severe forms of dengue in humans
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DOI：
10.1007/s00705-015-2433-z
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发表时间：
2015-07-01
影响因子：
2.7
通讯作者：
Valero, Nereida
中科院分区：
文献类型：
--
作者：
Duran, Anyelo;Carrero, Rafaela;Valero, Nereida
以前的研究表明循环脂质和登革病毒感染之间的关系，然而，改变脂质谱与严重登革的关联仍然很少研究。本研究的目的是确定循环脂质含量与严重登革热和/或血小板计数之间的关联。研究了98例（2-66岁）被分类为患有无警告信号（DNWS）的登革热、有警告信号（DWWS）的登革热或严重登革热（SD）的患者和62名健康个体。检测血液样本的NS 1、抗登革热IgM、血小板含量、总胆固醇（TC）、甘油三酯（T）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）。主要在SD患者中观察到脂质改变。在SD中观察到T和VLDL升高，在DWWS和SD中观察到HDL升高。在所有形式的登革热中发现TC降低，在SD中发现最低的LDL值。与DNWS相比，DWWS和SD的血小板计数显著降低。LDL值和血小板计数之间呈正相关（p = 0.019），VLDL值和血小板计数之间呈负相关（p = 0.0162）。
Previous studies have shown a relationship between circulating lipids and dengue virus infection; however, the association of altered lipid profiles with severe dengue remains little studied. The aim of this study was to determine the association between circulating lipid content and severe dengue and/or platelet counts. Ninety-eight patients (2-66 years old) classified as having dengue without warning signs (DNWS), dengue with warning signs (DWWS), or severe dengue (SD) and 62 healthy individuals were studied. Blood samples were tested for NS1, anti-dengue IgM, platelet content, total cholesterol (TC), triglycerides (T), high-density lipoproteins (HDL), low-density lipoproteins (LDL) and very-low-density lipoproteins (VLDL). Lipid alterations were observed mainly in patients with SD. Increased T and VLDL was observed in SD, and increased HDL was observed in DWWS and SD. Decreased TC was found in all forms of dengue, and the lowest LDL values were found in SD. Platelet counts were significantly decreased in DWWS and SD when compare to DNWS. A positive correlation (p = 0.019) between LDL values and platelet counts and a negative correlation (p = 0.0162) between VLDL values and platelet counts were found. Lipid profile alterations were associated with severe dengue.