The association of cardiovascular disease and metabolic syndrome with nephrolithiasis.
The association of cardiovascular disease and metabolic syndrome with nephrolithiasis.
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DOI：
10.1097/mou.0b013e32834fc31f
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发表时间：
2012-03
影响因子：
2.5
通讯作者：
Assimos DG
中科院分区：
文献类型：
--
作者：
Lange JN;Mufarrij PW;Wood KD;Holmes RP;Assimos DG
本文就肾结石、血管疾病与代谢综合征的关系作一综述。越来越多的证据表明，肾结石的形成与许多系统性问题有关，包括心血管疾病，代谢综合征及其组成部分。其中一些关联是双向的。这些关联的原因尚不完全清楚，但潜在因素包括与这些疾病相关的代谢反应，这些疾病促进尿液中的结石形成环境，环境因素如饮食，氧化应激和炎症以及影响尿液中某些分析物转运的分子变化。泌尿科医生需要认识到这些关联，因为他们可能有助于早期诊断重大医疗问题，或为患者提供咨询以防止其发生。
This review describes the relationship between nephrolithiasis, vascular disease and metabolic syndrome. There is increasing evidence that kidney stone formation is associated with a number of systemic problems including cardiovascular disease, metabolic syndrome and its components. Some of these associations are bidirectional. The reasons for these associations are not totally clear, but potential factors include metabolic responses associated with these disorders that promote a stone forming milieu in urine, environmental factors such as diet, oxidative stress and inflammation and molecular changes impacting the transport of certain analytes in urine. Urologists need to be cognizant of these associations as they may be able to contribute to an early diagnosis of a significant medical problem, or provide counseling to patients to prevent their occurrence.