Evaluation of Ultrafast Wave?Controlled Aliasing in Parallel Imaging 3D-FLAIR in the Visualization and Volumetric Estimation of Cerebral White Matter Lesions
Evaluation of Ultrafast Wave?Controlled Aliasing in Parallel Imaging 3D-FLAIR in the Visualization and Volumetric Estimation of Cerebral White Matter Lesions
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DOI：
10.3174/ajnr.a7191
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发表时间：
2021-07-08
影响因子：
3.5
通讯作者：
Huang, S. Y.
中科院分区：
文献类型：
--
作者：
Ngamsombat, C.;Goncalves Filho, A. L. M.;Huang, S. Y.
背景和目的：我们的目的是评估超快3D-FLAIR序列使用波？并行成像编码中的受控混叠（Wave-FLAIR）与标准3D-FLAIR在临床环境中对脑白色病变的可视化和体积估计中的比较。材料和方法：42例连续患者接受了3 T脑MR成像，包括标准3D-FLAIR（加速因子= 2，扫描时间= 7分50秒）和分辨率匹配的超快Wave-FLAIR序列（对于20通道线圈，加速因子= 6，扫描时间= 2分45秒;加速因子= 9，对于32通道线圈，扫描时间= 1分50秒）作为脱髓鞘疾病的临床评价的一部分。使用SPM中的病变分割工具对大脑白色病变进行自动分割。学生t检验，组内相关系数，相对病变体积差异，和骰子相似性系数被用来比较序列之间的体积测量。两名设盲的神经放射科医生使用预定义的5分量表评价了白色病变的可视化、伪影和总体诊断质量。研究结果：标准和Wave-FLAIR序列显示病变体积非常一致，组内相关系数为0.99，平均Dice相似系数为0.97（SD，0.05）（范围，0.84？0.99）。Wave-FLAIR在病变和运动的可视化方面不劣于标准FLAIR。对于幕下病变，Wave-FLAIR的诊断质量略高于标准FLAIR（P <0.001），与标准FLAIR相比，Wave-FLAIR的脉动伪影较少（P <0.001）。结论：Ultrafast Wave-FLAIR提供了上级的幕下病变可视化，同时保留了整体诊断质量，并产生与使用标准FLAIR估计的白质病变体积相当的白色病变体积。超快Wave-FLAIR的可用性可能有助于在疑似脱髓鞘疾病患者的评估中更多地使用3D-FLAIR序列。
BACKGROUND AND PURPOSE: Our aim was to evaluate an ultrafast 3D-FLAIR sequence using Wave?controlled aliasing in parallel imaging encoding (Wave-FLAIR) compared with standard 3D-FLAIR in the visualization and volumetric estimation of cerebral white matter lesions in a clinical setting. MATERIALS AND METHODS: Forty-two consecutive patients underwent 3T brain MR imaging, including standard 3D-FLAIR (acceleration factor = 2, scan time = 7 minutes 50 seconds) and resolution-matched ultrafast Wave-FLAIR sequences (acceleration factor = 6, scan time = 2 minutes 45 seconds for the 20-channel coil; acceleration factor = 9, scan time = 1 minute 50 seconds for the 32-channel coil) as part of clinical evaluation for demyelinating disease. Automated segmentation of cerebral white matter lesions was performed using the Lesion Segmentation Tool in SPM. Student t tests, intraclass correlation coefficients, relative lesion volume difference, and Dice similarity coefficients were used to compare volumetric measurements among sequences. Two blinded neuroradiologists evaluated the visualization of white matter lesions, artifacts, and overall diagnostic quality using a predefined 5-point scale. RESULTS: Standard and Wave-FLAIR sequences showed excellent agreement of lesion volumes with an intraclass correlation coefficient of 0.99 and mean Dice similarity coefficient of 0.97 (SD, 0.05) (range, 0.84?0.99). Wave-FLAIR was noninferior to standard FLAIR for visualization of lesions and motion. The diagnostic quality for Wave-FLAIR was slightly greater than for standard FLAIR for infratentorial lesions (P < .001), and there were fewer pulsation artifacts on Wave-FLAIR compared with standard FLAIR (P < .001). CONCLUSIONS: Ultrafast Wave-FLAIR provides superior visualization of infratentorial lesions while preserving overall diagnostic quality and yields white matter lesion volumes comparable with those estimated using standard FLAIR. The availability of ultrafast Wave-FLAIR may facilitate the greater use of 3D-FLAIR sequences in the evaluation of patients with suspected demyelinating disease.