Localized bioimpedance analysis in the evaluation of neuromuscular disease
Localized bioimpedance analysis in the evaluation of neuromuscular disease
复制标题
DOI：
10.1002/mus.10048
复制
发表时间：
2002-03-01
期刊：
影响因子：
3.4
通讯作者：
Shiffman, CA
中科院分区：
文献类型：
--
作者：
Rutkove, SB;Aaron, R;Shiffman, CA
局部生物阻抗分析是一种新的、无创的技术，在神经肌肉疾病中具有潜在的应用前景。在这个过程中，高频交流电通过肌肉，并评估与相应电压模式相关的参数。垂直于肌肉纤维的电流比平行于肌肉纤维的电流遇到更多的细胞膜，产生的表面电压模式会因疾病而改变。采用该技术对45名正常人和25名不同神经肌肉疾病患者进行了研究，其中肌萎缩性侧索硬化症患者4名，炎性肌病患者4名，包涵体肌炎患者11名。神经肌肉疾病患者的空间平均相位和有效纵向电阻率两个参数发生了改变，相位减少与疾病进展相关，而相位正常化与疾病缓解相关。在包涵体肌炎患者中，发现了一种独特的相位减少和电阻率升高的模式。这些发现表明，局部生物阻抗分析在神经肌肉疾病的诊断和治疗评价中具有重要的作用。(C) 2002 Wiley期刊有限公司
Localized bioimpedance analysis is a novel, noninvasive technique with potential application to neuromuscular disease. In this procedure, high-frequency alternating current is passed through muscle, and parameters related to the consequent voltage pattern are evaluated. Currents flowing perpendicular to muscle fibers encounter many more cell membranes than do currents flowing parallel to them, producing surface voltage patterns that are altered by disease. Using this technique, 45 normal subjects and 25 patients with various neuromuscular diseases were studied, including 4 with amyotrophic lateral sclerosis, 4 with inflammatory myopathy, and 11 with inclusion-body myositis, Two parameters, the spatially averaged phase and the effective longitudinal resistivity, were altered in patients with neuromuscular disease, Reductions in phase correlated to disease progression, whereas normalization of phase correlated with disease remission. In patients with inclusion-body myositis, a unique pattern of reduced phase and elevated resistivity was identified. These findings suggest that localized bioimpedance analysis has the potential of playing a substantial role in the diagnostic and therapeutic evaluation of neuromuscular disease. (C) 2002 Wiley Periodicals, Inc.