Factors associated with transmission of severe acute respiratory syndrome among health-care workers in Singapore
Factors associated with transmission of severe acute respiratory syndrome among health-care workers in Singapore
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DOI：
10.1017/s0950268804002766
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发表时间：
2004-10-01
影响因子：
4.2
通讯作者：
Leo, YS
中科院分区：
文献类型：
--
作者：
Teleman, MD;Boudville, IC;Leo, YS
2003年3月1日至22日期间，严重急性呼吸系统综合症（SARS）在新加坡Tan Tock Seng医院传染病中心爆发，该医院是国家治疗和隔离SARS患者的机构。对与SARS在医院内传播有关的因素进行了一项有36例病例和50例对照的病例对照研究。在单因素分析中，接触呼吸道分泌物将优势比提高到6.9 (95% CI 1（.) -34(.)）。6, P = 0(.) 02)。通过洗手获得保护（OR 0）。06, 95% ci 0(.) 07-0（.）5, P = 0()。03)和佩戴N95口罩（OR 0(0)）1,95 % ci 0(.)03-0（.）4, P = 0(001))。使用手套和防护服没有效果。多因素分析证实了呼吸道分泌物接触的重要作用（调整后的OR为21。）8, 95% ci 1(.)7-274（.）8日,P = 0(017))。双手清洗（调整或0(.)）07, 95% ci 0(.)008-0（.）66年,P = 0()。2)和佩戴N95口罩（调整OR 0(.)）1, 95% ci 0(.)02-0（.）86年,P = 0()。仍然具有很强的保护作用，但长袍和手套不起作用。
Between 1 and 22 March 2003, a nosocomial outbreak of Severe Acute Respiratory Syndrome (SARS) occurred at the Communicable Disease Centre in Tan Tock Seng Hospital, Singapore, the national treatment and isolation facility for patients with SARS. A case-control study with 36 cases and 50 controls was conducted of factors associated with the transmission of SARS within the hospital. In univariate analysis, contact with respiratory secretions elevated the odds ratio to 6.9 (95 % CI 1(.)4-34(.)6, P=0(.)02). Protection was conferred by hand washing (OR 0(.)06, 95 % CI 0(.)007-0(.)5, P=0(.)03) and wearing of N95 masks (OR 0(.)1, 95 % CI 0(.)03-0(.)4, P=0(.)001). Use of gloves and gowns had no effect. Multivariate analysis confirmed the strong role of contact with respiratory secretions (adjusted OR 21(.)8, 95 % CI 1(.)7-274(.)8, P=0(.)017). Both hand washing (adjusted OR 0(.)07, 95 % CI 0(.)008-0(.)66, P=0(.)02) and wearing of N95 masks (adjusted OR 0(.)1, 95% CI 0(.)02-0(.)86, P=0(.)04) remained strongly protective but gowns and gloves had no effect.