Prognostic Relevance of CD4(+), CD8(+) and FOXP3(+) TILs in Oral Squamous Cell Carcinoma and Correlations with PD-L1 and Cancer Stem Cell Markers.
Prognostic Relevance of CD4(+), CD8(+) and FOXP3(+) TILs in Oral Squamous Cell Carcinoma and Correlations with PD-L1 and Cancer Stem Cell Markers.
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DOI：
10.3390/biomedicines9060653
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发表时间：
2021-06-08
期刊：
影响因子：
4.7
通讯作者：
de Vicente JC
中科院分区：
文献类型：
--
作者：
Lequerica-Fernández P;Suárez-Canto J;Rodriguez-Santamarta T;Rodrigo JP;Suárez-Sánchez FJ;Blanco-Lorenzo V;Domínguez-Iglesias F;García-Pedrero JM;de Vicente JC
本研究探讨肿瘤浸润淋巴细胞（TIL）在口腔鳞状细胞癌（OSCC）中的相关性。对125例口腔鳞癌患者进行了间质/肿瘤CD 4+、CD 8+和FOXP 3 + TIL的免疫组化分析。评估了与肿瘤PD-L1和癌症干细胞（CSC）标志物（NANOG、SOX 2、OCT 4、巢蛋白和Podoplanin（PDPN））表达的潜在关系。CD 4+和CD 8 + TIL与吸烟和饮酒习惯显著相关。CD 4+和CD 8 + TILs与NANOG和SOX 2表达呈负相关，FOXP 3 + TILs与Nestin和PDPN表达显著相关。CD 4+和CD 8 + TIL的高浸润以及高肿瘤CD 8 +/FOXP 3+比率与具有阳性PD-L1表达的肿瘤显著相关。间质/肿瘤FOXP 3 + TIL的浸润和低间质CD 8 +/FOXP 3+比率与较好的疾病特异性存活显著相关。多因素分析显示，间质CD 8 +/FOXP 3 + TIL比率是显著的独立预后因素。关于OSCC患者的生存率，CD 8 +/FOXP 3 + TIL比率是独立的预后因素。TILs可作为OSCC的生物标志物和潜在的治疗靶点。
This study investigates the relevance of tumor-infiltrating lymphocytes (TILs) in oral squamous cell carcinoma (OSCC). Immunohistochemical analysis of stromal/tumoral CD4+, CD8+ and FOXP3+ TILs is performed in 125 OSCC patients. Potential relationships with the expression of tumoral PD-L1 and cancer stem cell (CSC) markers (NANOG, SOX2, OCT4, Nestin and Podoplanin (PDPN)) are assessed. CD4+ and CD8+ TILs are significantly associated with smoking and alcohol habits. CD4+ and CD8+ TILs show an inverse relationship with NANOG and SOX2 expression, and FOXP3+ TILs is significantly correlated with Nestin and PDPN expression. High infiltration of CD4+ and CD8+ TILs and a high tumoral CD8+/FOXP3+ ratio are significantly associated with tumors harboring positive PD-L1 expression. Infiltration of stromal/tumoral FOXP3+ TILs and a low stromal CD8+/FOXP3+ ratio are significantly associated with better disease-specific survival. Multivariate analysis reveals that the stromal CD8+/FOXP3+ TILs ratio is a significant independent prognostic factor. Regarding OSCC patient survival, the CD8+/FOXP3+ TILs ratio is an independent prognostic factor. TILs may act as biomarkers and potential therapeutic targets for OSCC.
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影响因子：
3.7
作者：
Homma, Yuki;Taniguchi, Koichi;Endo, Itaru
通讯作者：
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影响因子：
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