NOVEL ANTIFUNGAL ANTIBIOTICS OCTACOSAMICIN-A AND OCTACOSAMICIN-B .2. THE STRUCTURE ELUCIDATION USING VARIOUS NMR SPECTROSCOPIC METHODS
NOVEL ANTIFUNGAL ANTIBIOTICS OCTACOSAMICIN-A AND OCTACOSAMICIN-B .2. THE STRUCTURE ELUCIDATION USING VARIOUS NMR SPECTROSCOPIC METHODS
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DOI：
10.7164/antibiotics.41.1533
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发表时间：
1988-11-01
影响因子：
3.3
通讯作者：
TAKEUCHI, T
中科院分区：
文献类型：
--
作者：
DOBASHI, K;NAGANAWA, H;TAKEUCHI, T
用光谱法和化学修饰法研究了两种新的抗真菌抗生素八氨基菌素A和B的结构。二维核磁共振技术，包括1H-检测的杂原子多重键相关方法，成功地应用于本研究。这些抗生素具有独特的线性链结构，在末端具有N-羟基胍基。
The structures of octacosamicins A and B, two new antifungal antibiotics, were studied by spectrometries and chemical modifications. The 2D NMR techniques including 1H-detected heteronuclear multiple bond correlation method were successfully applied to this study. These antibiotics have unique linear chain structure possessing N-hydroxyguanidyl group at the terminal.