Diagnostic and Prognostic Value of Circulating Tumor Cells in Head and Neck Squamous Cell Carcinoma: a systematic review and meta-analysis.
Diagnostic and Prognostic Value of Circulating Tumor Cells in Head and Neck Squamous Cell Carcinoma: a systematic review and meta-analysis.
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DOI：
10.1038/srep20210
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发表时间：
2016-02-02
影响因子：
4.6
通讯作者：
Bittencourt Mde C
中科院分区：
文献类型：
--
作者：
Wu XL;Tu Q;Faure G;Gallet P;Kohler C;Bittencourt Mde C
已经开发了几种技术来检测头颈部鳞状细胞癌（HNSCC）患者的循环肿瘤细胞（CTC），但其诊断和预后价值尚未完全确定。2014年12月，使用电子数据库进行了计算机检索，没有时间限制。合并诊断准确性变量，并通过Meta-DiSc软件进行分析。采用Engauge Digitizer和Stata软件进行合并生存分析。22项检索到的研究符合系统评价的条件，其中9项符合诊断试验荟萃分析，5项符合预后分析。亚组分析显示，采用阳性选择策略检测的合并敏感性为24.6%，合并特异性为100%，且异质性较低。CTC的存在与较短的无病生存期显著相关（DFS，HR 4.62，95% CI 2.51-8.52）。总之，目前的证据表明，CTC检测试验在HNSCC中是一种特异性极高但灵敏度较低的检测方法。此外，CTC的存在表明DFS更差。
Several techniques have been developed to detect circulating tumor cells (CTC) in patients with head and neck squamous cell carcinoma (HNSCC), but their diagnostic and prognostic value are not yet fully established. A computerized retrieval of literatures was conducted without time restrictions using the electronic database in December 2014. Diagnostic accuracy variables were pooled and analyzed by the Meta-DiSc software. Engauge Digitizer and Stata software were used for pooled survival analysis. Twenty-two retrieved studies were eligible for systematic review, of which 9 conformed for the diagnostic test meta-analysis and 5 for the prognostic analysis. Subgroup analysis showed 24.6% pooled sensitivity and 100% pooled specificity of detections by using positive selection strategy, which moreover presented low heterogeneity. The presence of CTC was significantly associated with shorter disease free survival (DFS, HR 4.62, 95% CI 2.51–8.52). In conclusion, current evidence identifies the CTC detection assay as an extremely specific, but low sensitive test in HNSCC. Also, the presence of CTC indicates a worse DFS.