Subclonal Evolution of Cancer-Related Gene Mutations in p53 Immunopositive Patches in Human Skin
Subclonal Evolution of Cancer-Related Gene Mutations in p53 Immunopositive Patches in Human Skin
复制标题
DOI：
10.1016/j.jid.2017.07.844
复制
发表时间：
2018-01-01
影响因子：
6.5
通讯作者：
Healy, Eugene
中科院分区：
文献类型：
--
作者：
Albibas, Amel A.;Rose-Zerilli, Matthew J. J.;Healy, Eugene
正常暴露于阳光下的皮肤含有许多对p53蛋白染色呈阳性的表皮斑块（p53免疫阳性斑块，PIP），其被认为是皮肤癌的潜在早期前兆。虽然TP53基因在许多PIP中发生突变，但目前尚不清楚PIP是否含有任何其他癌症相关突变。在这里，我们报告说，PIP，主要是
Normal sun-exposed skin contains numerous epidermal patches that stain positive for p53 protein (p53 immunopositive patches, PIPs), which are considered potential early precursors of skin cancer. Although the TP53 gene is mutated in many PIPs, it is unclear whether PIPs contain any other cancer-related mutations. Here we report that PIPs, predominantly