Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal
Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal
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DOI：
10.1126/science.276.5321.2050
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发表时间：
1997-06-27
期刊：
影响因子：
56.9
通讯作者：
Weiss, F
中科院分区：
文献类型：
--
作者：
deFonseca, FR;Carrera, MRA;Weiss, F
促肾上腺皮质激素释放因子(CRF)参与了酒精、可卡因和阿片类药物戒断后应激样和负性情感后果的调节。这项研究试图确定大脑CRF系统是否也在大麻素依赖中发挥作用。大鼠每天服用强效合成大麻素HU-210治疗2周。由大麻素拮抗剂SR 141716A诱导的戒断伴随着细胞外CRF浓度的显著升高和中央核-杏仁核Fos的独特激活模式。CRF的最大增加对应于大麻素戒断引起的行为体征达到最大值的时间。这些数据表明，长期服用大麻素会改变大脑边缘系统的CRF功能，与其他滥用药物相似，并诱导神经适应过程，可能导致未来对药物依赖的脆弱性。
Corticotropin-releasing factor (CRF) has been implicated in the mediation of the stress-like and negative affective consequences oi withdrawal from drugs of abuse, such as alcohol, cocaine, and opiates. This study sought to determine whether brain CRF systems also have a role in cannabinoid dependence. Rats were treated daily for 2 weeks with the potent synthetic cannabinoid HU-210. Withdrawal, induced by the cannabinoid antagonist SR 141716A, was accompanied by a marked elevation in extracellular CRF concentration and a distinct pattern of Fos activation in the central nucleus:of the amygdala. Maximal increases in CRF corresponded lo the time when behavioral signs resulting from cannabinoid withdrawal were at a maximum. These data suggest that long-term cannabinoid administration alters CRF function in the limbic system of the brain, in a manner similar to that observed with other drugs of abuse, and also induces neuroadaptive processes that may result in future vulnerability to drug dependence.