Training-induced brain structure changes in the elderly
Training-induced brain structure changes in the elderly
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DOI：
10.1523/jneurosci.0742-08.2008
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发表时间：
2008-07-09
影响因子：
5.3
通讯作者：
May, Arne
中科院分区：
文献类型：
--
作者：
Boyke, Janina;Driemeyer, Joenna;May, Arne
有人提出，在健康的年轻志愿者中，学习与大脑灰质的短暂且高度选择性的增加有关。目前尚不清楚衰老的大脑是否以及在多大程度上仍然能够表现出这种结构可塑性。我们在最初的研究基础上进行了拓展，现在重点关注健康的老年人。我们观察到老年人能够学习三球抛接杂耍，但与20岁的青少年相比，熟练程度较低。与年轻组类似，在老年大脑中观察到与技能习得相关的灰质变化出现在hMT/V5区域（视觉皮层的颞中区）。此外，学会杂耍的老年志愿者左侧海马体以及双侧伏隔核的灰质出现了短暂增加。
It has been suggested that learning is associated with a transient and highly selective increase in brain gray matter in healthy young volunteers. It is not clear whether and to what extent the aging brain is still able to exhibit such structural plasticity. We built on our original study, now focusing on healthy senior citizens. We observed that elderly persons were able to learn three-ball cascade juggling, but with less proficiency compared with 20-year-old adolescents. Similar to the young group, gray-matter changes in the older brain related to skill acquisition were observed in area hMT/V5 (middle temporal area of the visual cortex). In addition, elderly volunteers who learned to juggle showed transient increases in gray matter in the hippocampus on the left side and in the nucleus accumbens bilaterally.