Smad4 suppresses the progression of renal cell carcinoma via the activation of forkhead box protein H1
Smad4 suppresses the progression of renal cell carcinoma via the activation of forkhead box protein H1
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DOI：
10.3892/mmr.2014.3061
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发表时间：
2015-04-01
影响因子：
3.4
通讯作者：
Chen, Zhaoyan
中科院分区：
文献类型：
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作者：
Liu, Yunli;Xu, Yangyang;Chen, Zhaoyan
Smad4最近被确定为多种癌症的肿瘤抑制基因，但Smad4在肾细胞癌（RCC）中的作用仍然难以捉摸。因此，本研究的目的是探讨Smad4在RCC中的功能。Smad4的表达降低了RCC的生长速度。与人肾上皮细胞相比，RCC细胞中Smad4和叉头盒蛋白H1 (FOXH1) mRNA水平降低，雌激素受体水平升高(P
Smad4 has recently been identified as a tumor suppressor gene in a variety of cancers, yet the role of Smad4 in renal cell carcinoma (RCC) remained to be elusive. Therefore, the aim of the present study was to explore the function of Smad4 in RCC. The expression of Smad4 reduced the growth rate of RCC. The levels of Smad4 and forkhead box protein H1 (FOXH1) mRNA were reduced, while the levels of estrogen receptor were increased in RCC cells compared with those in human renal epithelial cells (P