Non-extractable Polyphenols and Carotenoids - Importance in Human Nutrition and Health
Non-extractable Polyphenols and Carotenoids - Importance in Human Nutrition and Health
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不可提取的多酚和类胡萝卜素 - 对人类营养和健康的重要性
DOI：
10.1039/9781788013208-00241
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Havlik J
中科院分区：
文献类型：
--
作者：
Havlik J
肠道微生物群在促进健康方面的潜在作用越来越明显，但这些细菌也可能在疾病的发展中发挥关键作用。自从新一代测序技术、非靶向代谢组学和相关的复杂生物信息学出现以来，微生物组已与肥胖、代谢和心血管疾病、自身免疫性疾病、脑功能以及许多其他肠道和全身性疾病相关。这导致了在不同条件和疾病负担下调查肠道微生物组及其对人体代谢组影响的研究激增。同样，富含多酚的食物也被测试了它们对心血管风险因素的影响，包括炎症，以及它们对认知功能和衰退的影响。人类饮食中有许多不同的多酚，但只有少数能被上胃肠道吸收。其余的直接到达结肠
The potential role of the gut microbiome in promoting health has become increasingly evident, but these bacteria may also play a key role in the development of disease. Since the advent of next-generation sequencing techniques, non-targeted metabolomics and associated complex bioinformatics, the microbiome has been associated with obesity, metabolic and cardiovascular disease, autoimmune diseases, brain function and many other gut and systemic diseases. 1–5 This has resulted in an explosion of research investigating the gut microbiome and its impact on the human metabolome under different conditions and disease burdens. Similarly, polyphenol-rich foods have been tested for their effects on cardiovascular risk factors, including inflammation, and for their impact on cognitive function and decline. There are many different polyphenols in the human diet, but only few are well absorbed in the upper gastrointestinal tract. The rest reach the colon directly