Interferon-beta, but not tumor necrosis factor-alpha, production in response to poly I : C is maintained despite exhaustive exercise in mice
Interferon-beta, but not tumor necrosis factor-alpha, production in response to poly I : C is maintained despite exhaustive exercise in mice
复制标题
尽管小鼠进行了力竭运动，但对聚 I : C 的反应仍维持干扰素 β（而非肿瘤坏死因子 α）的产生
DOI：
10.1007/s12576-011-0177-4
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Yano H
中科院分区：
文献类型：
--
作者：
Uchida M;Oyanagi E;Kremenik MJ;Sasaki J;Yano H
目前尚不清楚剧烈运动是否会抑制对病毒感染的免疫反应。我们确定在注射合成双链（ds）RNA（一种聚核糖肌苷聚核糖胞苷酸（poly I:C））作为病毒感染模型后，力竭运动是否会抑制干扰素（IFN）-β和肿瘤坏死因子（TNF）-α的产生。将雄性 C3H/HeN 小鼠分为力竭运动组和未运动组，注射聚 I:C (5 mg/kg)。尽管力竭运动显着抑制了对聚 I:C 的 TNF-α 反应，但两组中的 IFN-β 没有差异。在体外实验中，儿茶酚胺抑制聚 I:C 诱导的巨噬细胞中 TNF-α 的产生，但不抑制 IFN-β 的产生。这些结果表明，尽管进行剧烈的压力运动，但对 Poly I:C 的抗病毒细胞因子 IFN-β 反应可能仍会维持。
It remains unclear whether immune response to viral infection is inhibited by severe exercise. We determined whether exhaustive exercise inhibits interferon (IFN)-β and tumor necrosis factor (TNF)-α production after injection of synthetic double-stranded (ds) RNAs, a polyriboinosinic polyribocytidylic acid (poly I:C), as viral infection model. Male C3H/HeN mice, which were divided into exhaustive-exercised and non-exercised groups, were injected with poly I:C (5 mg/kg). Although TNF-α in response to poly I:C was significantly inhibited by exhaustive exercise, IFN-β was no different in both groups. In in-vitro experiments, catecholamines inhibited poly I:C-induced TNF-α, but not IFN-β, production in macrophages. These results suggest that anti-virus cytokine IFN-β in response to poly I:C might be maintained despite severe stressful exercise.