The molecular basis of sperm capacitation.
The molecular basis of sperm capacitation.
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DOI：
10.1002/j.1939-4640.1998.tb01994.x
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发表时间：
1998-03
影响因子：
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通讯作者：
P. Visconti;H. Galantino-Homer;Grace D. Moore;Janice L. Bailey;Xiaoping Ning;Miguel W. Fornés;G. S. Kopf
中科院分区：
文献类型：
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作者：
P. Visconti;H. Galantino-Homer;Grace D. Moore;Janice L. Bailey;Xiaoping Ning;Miguel W. Fornés;G. S. Kopf
从形态学的角度来看，经历了精子发生和精子形成的睾丸精子似乎是成熟的，但既没有获得前向运动能力，也没有使中期II停滞的卵子受精的能力。在许多物种中，前向运动和受精能力是在附睾过程中获得的！运输，但体内完全受精能力只有在雌性生殖道中停留有限的时间后才能获得。赋予精子在女性生殖道中停留期间受精能力的分子和生理事件统称为“起搏”。这些成熟事件也可以在体外的成分确定的培养基中完成，其组成接近女性生殖道的环境。虽然获能是由Austin（1951，1952）和Chang（1951，1955）在近半个世纪前独立发现的，但迄今为止对这一重要事件的分子基础知之甚少。这篇简短的综述将考虑一些最近的研究结果，对理解获能使用体外模型。本综述的目的不是对能力培养进行详尽的分析，
Testicular sperm that have undergone spermatogeneis and spermiogenesis appear mature from a morphological standpoint but have acquired neither progressive motility nor the ability to fertilize a metaphase Il-arrested egg. In many species, progressive motility and fertilization competence are acquired during epididyma! transit, but complete fertilization capacity in vivo is only gained upon residence in the female reproductive tract for a finite period of time. The molecular and physiological events that confer on the sperm the ability to feftilize during residence in the female tract are collectively known as pacitation.” These maturational events can also be accomplished in vitro in defined media, the composition of which approximates the environment of the female reproductive tract. Although capacitation was discovered independently by Austin(1951, 1952) and Chang (1951, 1955) nearly one-half century ago, little is known to date about the molecular basis of this important event. This brief review will consider some of the recent findings made toward an understanding of capacitation using in vitro models. The purpose of this review is not to provide an exhaustive analysis of capacitation but is to offer an