Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery
Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery
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DOI：
10.1016/j.eclinm.2020.100463
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发表时间：
2020-08-01
影响因子：
15.1
通讯作者：
Xu, Ai-guo
中科院分区：
文献类型：
--
作者：
Zhao, Yu-miao;Shang, Yao-min;Xu, Ai-guo
背景：COVID-19幸存者的长期肺功能及相关生理特征研究尚未深入，许多方面尚不清楚。方法：招募COVID-19幸存者，于出院后3个月进行胸部、肺功能和血清SARS-CoV-2 IgG抗体水平检测的高分辨率计算机断层扫描（HRCT）。探讨临床特征与肺功能及CT评分的关系。结果：55例康复患者参与了本研究。其中35例出现SARS-CoV-2感染相关症状，39例出现不同程度的影像学异常。入院时尿素氮浓度与CT异常相关（P = 0.046, OR 7.149, 95% CI 1.038 ~ 49.216）。14例患者检测到肺功能异常，入院时测量d -二聚体水平可能有助于预测弥散缺陷受损（P = 0.031, OR 1.066, 95% CI 1.006至1.129）。55例患者血清SARS-CoV-2 IgG阳性47例，其中感染康复期女性患者免疫球蛋白G （IgG）抗体的产生强于男性患者。解释：在出院后3个月无危重病例的COVID-19幸存者中，仍有相当比例的放射学和生理异常。入院时较高的d -二聚体水平可有效预测出院3个月后DLCO受损情况。有必要对COVID-19患者进行随访，妥善处理任何持续或新出现的长期后遗症。(C) 2020作者。Elsevier Ltd.出版。
Background: The long-term pulmonary function and related physiological characteristics of COVID-19 survivors have not been studied in depth, thus many aspects are not understood.Methods: COVID-19 survivors were recruited for high resolution computed tomography (HRCT) of the thorax, lung function and serum levels of SARS-CoV-2 IgG antibody tests 3 months after discharge. The relationship between the clinical characteristics and the pulmonary function or CT scores were investigated.Findings: Fifty-five recovered patients participated in this study. SARS-CoV-2 infection related symptoms were detected in 35 of them and different degrees of radiological abnormalities were detected in 39 patients. Urea nitrogen concentration at admission was associated with the presence of CT abnormalities (P = 0.046, OR 7.149, 95% CI 1.038 to 49.216). Lung function abnormalities were detected in 14 patients and the measurement of D-dimer levels at admission may be useful for prediction of impaired diffusion defect (P = 0.031, OR 1.066, 95% CI 1.006 to 1.129). Of all the subjects, 47 of 55 patients tested positive for SARS-CoV-2 IgG in serum, among which the generation of Immunoglobulin G (IgG) antibody in female patients was stronger than male patients in infection rehabilitation phase.Interpretation: Radiological and physiological abnormalities were still found in a considerable proportion of COVID-19 survivors without critical cases 3 months after discharge. Higher level of D-dimer on admission could effectively predict impaired DLCO after 3 months discharge. It is necessary to follow up the COVID-19 patients to appropriately manage any persistent or emerging long-term sequelae. (C) 2020 The Authors. Published by Elsevier Ltd.