Efficient C-S Bond Formation by Direct Functionalization of C(sp3)-H Bond Adjacent to Heteroatoms under Metal-Free Conditions
Efficient C-S Bond Formation by Direct Functionalization of C(sp3)-H Bond Adjacent to Heteroatoms under Metal-Free Conditions
复制标题
在无金属条件下通过直接官能化邻近杂原子的 C(sp3)-H 键来有效形成 C-S 键
DOI：
10.1002/adsc.201900666
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发表时间：
2019
影响因子：
5.4
通讯作者：
Guo-Jun Deng
中科院分区：
文献类型：
--
作者：
Feng Zhao;Qi Tan;Jinjin Chen;Dahan Wang;Guo-Jun Deng
在无金属条件下，通过直接官能化邻近杂原子的C（sp3）−H键，得到了一种简单有效的C-S键.在这项工作中，稳定和容易获得的亚磺酸钠作为硫醇化剂，以中等至优异的产率提供各种芳基硫醚。机制的探索表明，一个激进的路径可能涉及在转变。
A simple and efficient method for the formation of C−S bondviadirect functionalization of C(sp3)−H bond adjacent to heteroatoms was described under metal‐free conditions. In this work, stable and easily accessible sodium sulfinates were used as the thiolating agents to afford various aryl thioethers in moderate to excellent yields. Mechanistic explorations show that a radical pathyway is possibly involved during the transformations.