The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration.
The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration.
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发表时间：
1996-02
期刊：
影响因子：
4.6
通讯作者：
B. Wightman;S. G. Clark;A. Taskar;W. Forrester;A. V. Maricq;Cori Bargmann;G. Garriga
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文献类型：
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作者：
B. Wightman;S. G. Clark;A. Taskar;W. Forrester;A. V. Maricq;Cori Bargmann;G. Garriga
线虫中神经系统的组装需要细胞的定向迁移，并且生长沿着身体前后轴和背腹轴进行。我们在此表明，基因 vab-8 对于细胞和生长锥的大多数向后定向迁移至关重要。 vab-8 的突变破坏了 17 个向后定向迁移中的 14 个，但仅破坏了 17 个向前定向和背腹侧迁移中的两个。对于向前和向后延伸轴突的两种类型的神经元，vab-8突变仅破坏向后定向的轴突的生长。 vab-8 编码两种遗传活性，可指导不同的迁移。我们的结果表明，大多数向后定向的细胞和生长锥迁移是由涉及 vab-8 基因的共同机制引导的。
The assembly of the nervous system in the nematode C. elegans requires the directed migrations of cells and growth comes along the anteroposterior and dorsoventral body axis. We show here that the gene vab-8 is essential for most posteriorly directed migrations of cells and growth cones. Mutations in vab-8 disrupt fourteen of seventeen posteriorly directed migrations, but only two of seventeen anteriorly directed and dorsoventral migrations. For two types of neurons that extend axons both anteriorly and posteriorly, vab-8 mutations disrupt only the growth of the posteriorly directed axon. vab-8 encodes two genetic activities that function in the guidance of different migrations. Our results suggest that most posteriorly directed cell and growth cone migrations are guided by a common mechanism involving the vab-8 gene.