The use of humanized mice for studies of viral pathogenesis and immunity
The use of humanized mice for studies of viral pathogenesis and immunity
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DOI：
10.1016/j.coviro.2018.03.003
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发表时间：
2018-04-01
影响因子：
5.9
通讯作者：
Ploss, Alexander
中科院分区：
文献类型：
--
作者：
Douam, Florian;Ploss, Alexander
人源化小鼠，即植入人体组织和/或表达人类基因的动物，有助于提高我们对定义一些最具挑战性的人类病毒的发病机制和免疫学过程的理解。特别是，植入人类免疫系统（HIS）成分的小鼠为人类对感染的免疫反应的机制研究提供了前所未有的机会。在这里，我们简要概述了当前可用的 HIS 小鼠模型，并引用了最近如何使用此类人源化动物来研究嗜人类病毒引起的免疫反应和发病机制的例子。最后，我们将概述未来面临的一些挑战以及改进和完善人源化小鼠的策略，其目标是更准确地再现人类对病毒感染的免疫反应。
Humanized mice, that is, animals engrafted with human tissues and/or expressing human genes, have been instrumental in improving our understanding of the pathogenesis and immunological processes that define some of the most challenging human-tropic viruses. In particular, mice engrafted with components of a human immune system (HIS) offer unprecedented opportunities for mechanistic studies of human immune responses to infection. Here, we provide a brief overview of the current panel of HIS mouse models available and cite recent examples of how such humanized animals have been used to study immune responses and pathogenesis elicited by human-tropic viruses. Finally, we will outline some of the challenges that lay ahead and strategies to improve and refine humanized mice with the goal of more accurately recapitulating human immune responses to viral infection.