Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk.
Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk.
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DOI：
10.1093/ajcn/73.1.61
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
T. Fung;E. Rimm;D. Spiegelman;N. Rifai;G. Tofler;W. Willett;F. Hu
中科院分区：
文献类型：
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作者：
T. Fung;E. Rimm;D. Spiegelman;N. Rifai;G. Tofler;W. Willett;F. Hu
背景：虽然许多研究已经研究了个别食物或营养物质对疾病发展的影响及其危险因素，但对总体饮食结构的影响还没有引起足够的重视。目的探讨西式和谨慎两种主要饮食模式与肥胖和心血管疾病(CVD)风险的关系。设计通过使用1994年食物频率问卷(FFQs)收集的饮食信息，我们使用因子分析来确定健康专业人员跟踪研究中的一组男性(n=466)的主要饮食模式。我们计算了根据年龄、吸烟状况、能量和酒精摄入量、体力活动、看电视时间和体重指数调整后的模式得分和生物标志物值之间的偏相关系数。结果我们得出了两种主要的饮食模式，这些模式随着时间的推移通常是可重复的。第一种模式(审慎)的特点是水果、蔬菜、全谷物和家禽的摄入量较高。第二种模式(西部)的特点是红肉、高脂肪乳制品和精制谷物的摄入量较高。使用1994年以来的模式评分并调整潜在的混杂因素，我们发现Western模式与胰岛素、C-肽、瘦素和同型半胱氨酸浓度显著正相关，而与血浆叶酸浓度负相关。谨慎模式与血浆叶酸呈正相关，与胰岛素和同型半胱氨酸浓度呈负相关。结论主要膳食结构是心血管疾病和肥胖风险的血浆生物标志物的预测因子，提示总体饮食对心血管疾病风险的影响可能是通过这些生物标志物来实现的。
BACKGROUND Although the effects of individual foods or nutrients on the development of diseases and their risk factors have been investigated in many studies, little attention has been given to the effect of overall dietary patterns. OBJECTIVE Our objective was to examine the associations of 2 major dietary patterns, Western and prudent, with biomarkers of obesity and cardiovascular disease (CVD) risk. DESIGN We used factor analysis to define major dietary patterns for a subsample of men (n = 466) from the Health Professionals Follow-up Study by using dietary information collected from food-frequency questionnaires (FFQs) in 1994. We calculated partial correlation coefficients between pattern scores and biomarker values adjusted for age, smoking status, energy and alcohol intake, physical activity, hours of television watching, and body mass index. RESULTS We derived 2 major dietary patterns that were generally reproducible over time. The first pattern (prudent) was characterized by higher intakes of fruit, vegetables, whole grains, and poultry. The second pattern (Western) was characterized by higher intakes of red meats, high-fat dairy products, and refined grains. Using pattern scores from 1994 and adjusting for potential confounders, we found significant positive correlations between the Western pattern and insulin, C-peptide, leptin, and homocysteine concentrations, and an inverse correlation with plasma folate concentrations. The prudent pattern was positively correlated with plasma folate and inversely correlated with insulin and homocysteine concentrations. CONCLUSION Major dietary patterns are predictors of plasma biomarkers of CVD and obesity risk, suggesting that the effect of overall diet on CVD risk may be mediated through these biomarkers.