Nucleoside Uptake by Slices of Mouse Brain
Nucleoside Uptake by Slices of Mouse Brain
复制标题
小鼠大脑切片对核苷的摄取
DOI：
10.1111/j.1471-4159.1980.tb03689.x
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发表时间：
1980
影响因子：
4.7
通讯作者：
A. Lajtha
中科院分区：
文献类型：
--
作者：
M. Banay‐Schwartz;T. Guzman;A. Lajtha
：在小鼠脑切片中检查了脑细胞摄取核苷和核苷酸的特性。在测试的化合物中，腺嘌呤和腺苷的吸收最快并达到最高水平。吸收是由饱和度和强抑制、低温或氰化物介导的，并且仅部分依赖于钠或钙。类似物的抑制模式表明存在几个摄取系统（可能是四个），如腺嘌呤和鸟嘌呤摄取之间、腺嘌呤和腺苷摄取之间以及腺苷和胞苷摄取之间的差异所示。核苷酸和核苷的摄取系统的特性与氨基酸的摄取系统有些不同。
: The properties of the uptake of nucleosides and nucleotides by brain cells were examined in slices of mouse brain. Of the compounds tested, adenine and adenosine had the most rapid uptake and reached the highest levels. Uptake was mediated, as shown by saturability and strong inhibition, by low temperature, or by cyanide, and was only partially sodium‐ or calcium‐dependent. The inhibition pattern by analogues indicated the presence of several uptake systems (possibly four), as shown by differences between adenine and guanine uptake, between adenine and adenosine uptake, and between adenosine and cytidine uptake. The properties of uptake systems for nucleotides and nucleosides were somewhat different from those for amino acids.